Merck 2006 Annual Review » Five Patients

Merck’s focus on discovering and developing medicines and vaccines has resulted in products that have helped millions of patients around the world.

We plan to drive the continued success of our franchises through new products, new indications and formulations for existing products, and clinical trials that demonstrate their safety and efficacy. Following is a list of selected Merck medicines and vaccines.

Arcoxia® (etoricoxib)	Osteoarthritis Rheumatoid arthritis (adult) Acute pain Ankylosing spondylitis	Chronic low back pain Dysmenorrhea (menstrual pain) Acute gouty arthritis

Cancidas® (caspofungin acetate)	Empiric therapy for presumed fungal infections for febrile, neutropenic patients Treatment of invasive aspergillosis in patients who did not respond to or were intolerant of other antifungal therapies Candida infections: intra-abdominal abscesses, peritonitis (infections within the lining of the abdominal cavity), pleural space infections (infections within the lining of the lung) Candidemia (bloodstream infection) Esophageal candidiasis

Comvax® [Haemophilus b conjugate (meningococcalprotein conjugate) and hepatitis B (recombinant) vaccine]	Simultaneous vaccination against Haemophilus influenzae type b disease and hepatitis B disease in infants 6 weeks to 15 months of age

Cosopt® (dorzolamide hydrochloride and timolol maleate)	Lower intraocular pressure

Cozaar® (losartan potassium)	High blood pressure Reduction in progression of renal disease in patients with type 2 diabetes, hypertension and nephropathy Reduction of stroke risk in patients with hypertension and left ventricular hypertrophy(1)

Crixivan® (indinavir sulfate)	Treatment of HIV infection in combination with antiretroviral agents

Emend® (aprepitant)	Prevention of nausea and vomiting induced by highly emetogenic chemotherapy Prevention of nausea and vomiting induced by moderately emetogenic chemotherapy Prevention of postoperative nausea and vomiting

Fosamax® (alendronate sodium)	Treatment and prevention of postmenopausal osteoporosis Reduction of osteoporotic fracture risk in postmenopausal women Treatment to increase bone mass in men with osteoporosis Treatment of glucocorticoid-induced osteoporosis Paget’s disease of the bone

Fosamax Plus D™ (alendronate sodium/cholecalciferol)	Treatment of osteoporosis in postmenopausal women Treatment to increase bone mass in men with osteoporosis

Gardasil® [quadrivalent human papillomavirus (Types 6, 11, 16, 18) recombinant vaccine]	Vaccination against cervical cancer, cervical lesions, vulvar lesions, vaginal lesions and genital warts caused by HPV types 6, 11, 16, and 18 in girls and young women ages 9 to 26

Hyzaar® (losartan potassium and hydrochlorothiazide)	High blood pressure Reduction of stroke risk in patients with hypertension and left ventricular hypertrophy(1)

Invanz® (ertapenem sodium)	Treatment of moderate to severe infections caused by susceptible strains of aerobic and anaerobic bacteria, such as complicated intra-abdominal and complicated skin and skin structure infections Treatment of moderate to severe complicated foot infection due to indicated pathogens in diabetic patients without osteomyelitis

Januvia™ (sitagliptin phosphate)	Type 2 diabetes

Maxalt® (rizatriptan benzoate)	Acute migraine

M-M-R® II (measles, mumps and rubella virus vaccine live)	Simultaneous vaccination against measles, mumps, rubella (German measles) in individuals 12 months of age and older

Pneumovax® 23 (pneumococcal vaccine polyvalent)	Vaccination against pneumococcal disease

Primaxin® (imipenem and cilastatin)	Antibiotic

Propecia® (finasteride)	Treatment of male pattern hair loss

ProQuad® [measles, mumps,rubella and varicella (Oka/Merck) virus vaccine live]	Simultaneous vaccination against measles, mumps, rubella (German measles) and varicella (chickenpox) in children 12 months to 12 years of age

Proscar® (finasteride)	Treatment of symptomatic benign prostate enlargement

Recombivax HB® [hepatitis B vaccine (recombinant)]	Vaccination against hepatitis B

RotaTeq® (rotavirus vaccine, live, oral pentavalent)	Vaccination against rotavirus gastroenteritis in infants

Singulair® (montelukast sodium)	Chronic asthma—adults and children as young as 12 months old Seasonal allergic rhinitis—adults and children as young as age 2 Perennial allergic rhinitis (indoor/year-round allergies)— in adults and children 6 months of age and older

Stocrin® (efavirenz)(2)	HIV infection

Timoptic-XE® (timolol maleate ophthalmic gel forming solution)	Lower intraocular pressure

Trusopt® (dorzolamide hydrochloride)	Lower intraocular pressure

Vaqta® (hepatitis A vaccine inactivated)	Vaccination against hepatitis A in individuals 12 months of age and older

Varivax® [varicella virus vaccine live (Oka/Merck)]	Vaccination against chickenpox in individuals 12 months of age and older

Vytorin® (ezetimibe simvastatin)(3)	Elevated total cholesterol levels Lower LDL cholesterol	Raise HDL cholesterol Reduce triglycerides

Zetia® (ezetimibe)(3)	Elevated cholesterol levels

Zolinza™ (vorinostat)	Treatment of cutaneous T-cell lymphoma (CTCL)

Zostavax® [zoster vaccine live (Oka/Merck)]	Vaccination against shingles in adults 60 and older

⁽¹⁾ There is evidence that this benefit does not apply to black patients.
⁽²⁾ Efavirenz is marketed by Bristol-Myers Squibb as Sustiva in the U.S., Canada and certain European countries, and by Merck in the rest of the world as Stocrin.
⁽³⁾ Vytorin (marketed as Inegy outside the U.S.) and Zetia (marketed as Ezetrol outside the U.S.) are marketed through a partnership with Schering-Plough Corporation.