MERCK 2007 Annual Review » Medicines & Vaccines

Merck’s focus on discovering and developing medicines and vaccines has resulted in products that have helped millions of patients around the world. We continue to grow our business with new product indications and formulations, as well as clinical trials that demonstrate their benefits. Following is a list of selected Merck medicines and vaccines. For more information on Merck products, including complete prescribing information, please visit www.merck.com.

Atherosclerosis & Cardiovascular

Cozaar^® (losartan potassium): – High blood pressure
Hyzaar^® (losartan potassium and hydrochlorothiazide): – High blood pressure
Vytorin^® (ezetimibe/simvastatin)⁽¹⁾: – High cholesterol
Zetia^® (ezetimibe)⁽¹⁾: – High cholesterol

Diabetes & Obesity

Janumet^® (sitagliptin/metformin HCl): – Type 2 diabetes
Januvia^® (sitagliptin phosphate): – Type 2 diabetes

Infectious Diseases

Atripla^® (efavirenz 600mg/ emtricitabine 200 mg/tenofovir disoproxil fumarate 300 mg) ⁽²⁾: – HIV infection
Cancidas^® (caspofungin acetate): – Certain fungal infections
Crixivan^® (indinavir sulfate): – HIV infection
Invanz^® (ertapenem sodium): – Certain bacterial infections
Isentress^® (raltegravir): – HIV infection
Primaxin^® (imipenem and cilastatin): – Certain bacterial infections
Stocrin^® (efavirenz)⁽³⁾: – HIV infection

Neuroscience & Ophthalmology

Cosopt^® (dorzolamide hydrochloride and timolol maleate): – Elevated intraocular pressure
Maxalt^® (rizatriptan benzoate): – Acute migraine
Timoptic-XE^® (timolol maleate ophthalmic gel forming solution): – Elevated intraocular pressure
Trusopt^® (dorzolamide hydrochloride): – Elevated intraocular pressure

Oncology

Emend^® (aprepitant): – Prevention of postoperative or chemotherapy-induced nausea and vomiting
Emend^® for Injection (fosaprepitant dimeglumine): – Intravenous prevention of chemotherapy-induced nausea and vomiting
Zolinza^® (vorinostat): – Cancer [cutaneous T-cell lymphoma (CTCL)]

Respiratory, Bone, Arthritis & Analgesia

Arcoxia^® (etoricoxib): – Pain and arthritis
Fosamax^® (alendronate sodium): – Osteoporosis
Fosamax Plus D^® (alendronate sodium/cholecalciferol): – Osteoporosis
Singulair^® (montelukast sodium): – Asthma, indoor and outdoor allergies

Specialty

Propecia^® (finasteride): – Male pattern hair loss

Vaccines

Comvax^® [Haemophilus b conjugate (meningococcal protein conjugate) and hepatitis B (recombinant) vaccine]: – Haemophilus influenzae type b and hepatitis B
Gardasil^® [human papillomavirus quadrivalent (types 6, 11, 16, 18) vaccine, recombinant]: – Cervical cancer, cervical lesions, vulvar lesions, vaginal lesions and genital warts caused by HPV types 6, 11, 16, and 18
M-M-R^® II (measles, mumps and rubella virus vaccine live): – Measles, mumps, rubella (German measles)
PedvaxHIB^® [Haemophilus b conjugate vaccine (meningococcal protein conjugate)]: – Haemophilus influenzae type b
Pneumovax^® 23 (pneumococcal vaccine polyvalent): – Pneumococcal disease
ProQuad^® [measles, mumps, rubella and varicella (Oka/Merck) virus vaccine live]: – Measles, mumps, rubella (German measles) and chickenpox
Recombivax HB^® [hepatitis B vaccine (recombinant)]: – Hepatitis B
RotaTeq^® (rotavirus vaccine, live, oral pentavalent): – Rotavirus
Vaqta^® (hepatitis A vaccine inactivated): – Hepatitis A
Varivax^® [varicella virus vaccine live (Oka/Merck)]: – Chickenpox
Zostavax^® (zoster vaccine live): – Shingles

⁽¹⁾ Vytorin (marketed as Inegy outside the United States) and Zetia (marketed as Ezetrol outside the United States) are marketed through a partnership with Schering-Plough Corporation. ⁽²⁾ Atripla is marketed by Bristol-Myers Squibb and Gilead in the United States, Canada and Europe. Merck and Gilead are working to register and distribute Atripla in 94 developing countries around the world. ⁽³⁾ Efavirenz is marketed by Bristol-Myers Squibb as Sustiva in the United States, Canada and certain European countries, and by Merck in the rest of the world as Stocrin.

2007 Annual Review

Our Medicines and Vaccines