For allergies affecting the nose and respiratory tract (such as hay fever), OTC antihistamines that can be taken by mouth are available (see Allergic Reactions: Antihistamines). Examples are chlorpheniramine and diphenhydramine. Taking an antihistamine to treat allergies requires the same precautions as taking a cold remedy containing an antihistamine (see Over-the-Counter (OTC) Drugs: Antihistamines). (Several new antihistamines that have fewer side effects are available, but most require a prescription.)

For allergies affecting the skin (such as poison ivy), creams or lotions that contain an antihistamine, such as diphenhydramine, can be applied to the skin (see Diagnosis and Treatment of Skin Disorders: Topical Preparations). Lotions, creams, and ointments that contain hydrocortisone, a corticosteroid, are effective in relieving itching associated with allergies, minor skin irritations, and inflammation. Long-term use of corticosteroid products can cause side effects, such as irreversible thinning and redness of the skin, but the risk with hydrocortisone is minimal.

Last full review/revision February 2003