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THE MERCK MANUAL MEDICAL LIBRARY: The Merck Manual of Medical Information--Home Edition
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A person's genetic makeup is a complete set of instructions on how the body is “supposed” to be built. The body's genetic material consists of genes, made up of coils of deoxyribonucleic acid (DNA). Genes are contained in chromosomes, which are mainly in the cell nucleus.

Structure of DNA

Structure of DNA

DNA (deoxyribonucleic acid) is the cell's genetic material, contained in chromosomes within the cell nucleus and mitochondria.

Except for certain cells (for example, sperm and egg cells and red blood cells), the cell nucleus contains 23 pairs of chromosomes. A chromosome contains many genes. A gene is a segment of DNA that provides the code to construct proteins.

The DNA molecule is a long, coiled double helix that resembles a spiral staircase. In it, two strands, composed of sugar (deoxyribose) and phosphate molecules, are connected by pairs of four molecules called bases, which form the steps of the staircase. In the steps, adenine is paired with thymine, and guanine with cytosine. Each pair of bases is held together by a hydrogen bond. A gene consists of a sequence of bases. Sequence of three bases code for an amino acid (amino acids are the building blocks of proteins) or other information.

Last full review/revision August 2007 by Judith G. Hall, MD

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Next: Chromosomes and Genes

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