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Pronunciations agammaglobulinemia arthritis ataxia-telangiectasia B lymphocytes candidiasis cutaneous granuloma granulomatous hypogammaglobulinemia immunoglobulin lymphocytes mucocutaneous candidiasis pneumonia telangiectasia thyroiditis

Common variable immunodeficiency is an acquired immunodeficiency disorder resulting in very low antibody levels despite a normal number of B lymphocytes.

Common variable immunodeficiency usually develops between the ages of 10 and 20. In some people with this disorder, T lymphocytes malfunction. Recurring lung infections, particularly pneumonia, are common. Autoimmune disorders, including Addison's disease, thyroiditis, and rheumatoid arthritis, often develop. Diarrhea may occur, and food may not be absorbed well from the digestive tract.

Infusions of immune globulin are given throughout life, and antibiotics are promptly given to treat infections. Lifespan may be shortened.

Last full review/revision February 2003