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Pronunciations arthritis conjunctivitis cyclophosphamide keratitis keratoconus keratomalacia keratopathy peripheral ulcerative keratitis T4

Peripheral ulcerative keratitis is inflammation and ulceration of the cornea that often occurs in people who have connective tissue diseases such as rheumatoid arthritis.

Peripheral ulcerative keratitis is probably caused by an autoimmune reaction (see Autoimmune Disorders). People develop blurred vision, increased sensitivity to bright light, and a sensation of a foreign object trapped in the eye. The ulcer is located in the periphery of the cornea and is usually oval in shape.

Of the people who have rheumatoid arthritis and peripheral ulcerative keratitis, about 40% die (mostly due to a heart attack) within 10 years of developing peripheral ulcerative keratitis unless they are treated. Treatment with drugs that suppress the immune system, such as oral or intravenous cyclophosphamide Some Trade Names
LYOPHILIZED CYTOXAN
, reduces the death rate to about 8% in 10 years.

Last full review/revision October 2008 by Melvin I. Roat, MD