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Triple X (trisomy
X, XXX) syndrome is a rare disorder in which female infants are
born with three X chromosomes.
Girls with triple X syndrome tend to have slightly lower intelligence and particular problems with verbal skills. Sometimes the syndrome causes menstrual irregularities and infertility, although some women with triple X syndrome have given birth to physically normal children who have normal chromosomes.
Extremely rare cases of infants with four or even five X chromosomes have been identified. The more X chromosomes the girl has, the greater the chance of mental retardation and physical abnormalities.
Last full review/revision December 2008 by Gregory S. Liptak, MD, MPH
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