Epiglottitis is a rapidly progressive bacterial infection of the epiglottis and surrounding tissues that may lead to sudden respiratory obstruction and death. Symptoms include severe sore throat, dysphagia, high fever, drooling, and inspiratory stridor. Diagnosis requires direct visualization of the supraglottic structures, which is not to be done until full respiratory support is available. Treatment includes airway protection and antibiotics.

Epiglottitis used to be primarily a disease of children and usually was caused by Haemophilus influenzae type B. Now, because of widespread vaccination, it has been almost eradicated in children (more cases occur in adults). Causal organisms in children and adults include Streptococcus pneumoniae, Staphylococcus aureus, nontypeable H. influenzae, Haemophilus parainfluenzae, β-hemolytic streptococci, Branhamella catarrhalis, and Klebsiella pneumoniae. H. influenzae type B is still a cause in adults and unvaccinated children.

Bacteria that have colonized the nasopharynx spread locally to cause supraglottic cellulitis with marked inflammation of the epiglottis, vallecula, aryepiglottic folds, arytenoids, and laryngeal ventricles. With H. influenzae type B, infection may spread hematogenously.

The inflamed supraglottic structures mechanically obstruct the airway, increasing the work of breathing, ultimately causing respiratory failure. Clearance of inflammatory secretions also is impaired.

Symptoms and Signs

In children, sore throat, odynophagia, and dysphagia develop abruptly. Fatal asphyxia may occur within a few hours of onset. Drooling is very common. Additionally, the child has signs of toxicity (poor or absent eye contact, failure to recognize parents, cyanosis, irritability, inability to be consoled or distracted) and is febrile and anxious. Dyspnea, tachypnea, and inspiratory stridor may be present, often causing the child to sit upright, lean forward, and hyperextend the neck with the jaw thrust forward and mouth open in an effort to enhance air exchange (tripod position). Relinquishing this position may herald respiratory failure. Suprasternal, supraclavicular, and subcostal inspiratory retractions may be present.

In adults, symptoms are similar to those of children, including sore throat, fever, dysphagia, and drooling, but peak symptoms usually take > 24 h to develop. Because of the larger diameter of the adult airway, obstruction is less common and less fulminant. Often, there is no visible oropharyngeal inflammation. However, severe throat pain with a normal-appearing pharynx raises suspicion of epiglottitis.

Diagnosis

• Direct inspection (typically in operating room)
• X-ray in milder cases with low suspicion

Epiglottitis is suspected in patients with severe sore throat and no pharyngitis and also in patients with sore throat and inspiratory stridor. Stridor in children may also result from croup (viral laryngotracheal bronchitis—Table 1: Oral and Pharyngeal Disorders: Differentiating Epiglottitis From Croup and see Respiratory Disorders in Neonates, Infants, and Young Children: Croup), bacterial tracheitis, and airway foreign body. The tripod position may also occur with peritonsillar or retropharyngeal abscess.

Table 1
Differentiating Epiglottitis From Croup Feature Epiglottitis Croup* Onset Acute and fulminant More gradual Age Commonly, 2-8 yr (if not vaccinated against Haemophilus influenzae type B) and adults Commonly, 6–36 mo Barking cough Uncommon Characteristic Epiglottis Edematous and cherry red May be erythematous Neck x-ray findings Enlarged epiglottis (thumb sign) and distention of the hypopharynx Subepiglottic narrowing (steeple sign) and a normal-sized epiglottis *Also called viral laryngotracheal bronchitis.

The patient is hospitalized if epiglottitis is suspected. Diagnosis requires direct examination, usually with flexible fiberoptic laryngoscopy. (Caution: Examination of the pharynx and larynx may precipitate complete respiratory obstruction in children, and the pharynx and larynx should not be directly examined except in the operating room, where the most advanced airway intervention is available.) Although plain x-rays may be helpful, a child with stridor should not be transported to the x-ray suite. Direct laryngoscopy that reveals a beefy-red, stiff, edematous epiglottis is diagnostic. Cultures from the supraglottic tissues and blood can then be taken to search for the causative organism.

Adults may, in some cases, safely undergo flexible fiberoptic laryngoscopy.

Treatment

• Adequate airway ensured
• Antibiotics (eg, ceftriaxone)

In children, the airway must be secured immediately, preferably by nasotracheal intubation. Securing the airway can be quite difficult and should, if possible, be done by experienced personnel in the operating room. An endotracheal tube is usually required until the patient has been stabilized for 24 to 48 h (usual total intubation time is < 60 h). Alternatively, a tracheotomy is done. If respiratory arrest occurs before an airway is established, bag-mask ventilation may be a life-saving temporary measure. For emergency care of children with epiglottitis, each institution should have a protocol that involves critical care, otolaryngology, anesthesia, and pediatrics.

Adults whose airway is severely obstructed can be endotracheally intubated during flexible fiberoptic laryngoscopy. Other adults may not require immediate intubation but should be observed for airway compromise in an ICU with an intubation set and cricothyrotomy tray at the bedside.

A β-lactamase–resistant antibiotic, such as ceftriaxone 50 to 75 mg/kg IV once/day (maximum 2 g), should be used empirically, pending culture and sensitivity test results.

Epiglottitis caused by H. influenzae type B can be effectively prevented with the H. influenzae type B (Hib) conjugate vaccine.

Last full review/revision July 2008 by Clarence T. Sasaki, MD