Blepharospasm is spasm of muscles around the eye causing involuntary blinking and eye closing.

The cause of blepharospasm is most often unknown. It affects women more than men and tends to occur within families. Blepharospasm may also be secondary to eye disorders, including those that cause ocular irritation (eg, trichiasis, corneal foreign body, keratoconjunctivitis sicca) and systemic neurologic diseases that cause spasm (eg, Parkinson's disease).

Symptoms are involuntary blinking and closing of the eyes; in severe cases, people cannot open their eyes. Spasms may be made worse by fatigue, bright light, and anxiety. Treatment involves injecting botulinum toxin type A into the eyelid muscles; treatment must be repeated in most instances. Anxiolytics may help. Surgery to cut the periorbital muscles is also effective but, because of potential complications, is considered only if botulinum toxin fails. Sunglasses help decrease the light sensitivity that may cause or accompany blepharospasm.

Last full review/revision November 2007 by James Garrity, MD