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Rabies
is a viral encephalitis transmitted by the saliva of infected bats
and certain infected mammals. Symptoms include depression and fever, followed
by agitation, excessive salivation, and hydrophobia. Diagnosis is
by serologic tests or biopsy. Vaccination is indicated for people
at high risk of exposure. Postexposure prophylaxis involves wound
care and passive and active immunoprophylaxis. The disorder is almost universally
fatal. Treatment is supportive.
Rabies causes > 50,000 human deaths worldwide annually, mostly in Latin America, Africa, and Asia, where canine rabies is endemic. In the US, vaccination of domestic animals has reduced rabies cases in people to < 6/yr, mostly transmitted by infected bats. Infected raccoons, skunks, and foxes can also transmit rabies.
Rabid animals transmit the infection through their saliva, usually by biting. Rarely, the virus can enter through a skin abrasion or across mucous membranes of the eyes, nose, or mouth. The virus travels from the site of entry via peripheral nerves to the spinal cord (or to the brain stem when the face is bitten), then to the brain. It spreads from the CNS via peripheral nerves to other parts of the body. Involvement of the salivary glands and oral mucosa is responsible for transmissibility.
Symptoms and Signs
Pain or paresthesias may develop at the site of the bite. Rapidity of progression depends on the viral inoculum and proximity of the wound to the brain. The incubation period averages 1 to 2 mo but may be > 1 yr. Initial symptoms are nonspecific: fever, headache, and malaise. Within days, encephalitis (“furious” rabies; in 80%) or paralysis (“dumb” rabies; in 20%) develops. Encephalitis causes restlessness, confusion, agitation, bizarre behavior, hallucinations, and insomnia. Salivation is excessive, and attempts to drink produce painful spasms of the laryngeal and pharyngeal muscles (hydrophobia). In the paralytic form, ascending paralysis and quadriplegia develop without delirium and hydrophobia.
Diagnosis
and Treatment
Rabies is suspected in patients with encephalitis or ascending paralysis and a history of an animal bite or exposure to bats; bat bites may be superficial and overlooked. Direct fluorescence antibody testing of a biopsy specimen of skin from the nape of the neck is the diagnostic test of choice. Diagnosis can also be made by PCR of CSF, saliva, or tissue. Specimens tested for rabies antibodies include serum and CSF. CT, MRI, and EEG are normal or show nonspecific changes.
Death usually occurs 3 to 10 days after symptoms begin. Only a handful of patients have survived, all of whom received immunoprophylaxis before onset of symptoms. Treatment is only supportive and includes sedation and comfort measures.
Prevention
Rabid animals can often be recognized by their strange behavior; they may be agitated and vicious, weak, or paralyzed and may show no fear of people. Nocturnal animals (eg, bats, skunks, raccoons) may be out during the day. Bats may make unusual noises and have difficulty flying. An animal suspected of having rabies should not be approached. Local health authorities should be contacted to remove the animal.
Exposure is considered to be a bite that breaks the skin or any contact between mucous membrane or broken skin and animal saliva. If exposure occurs, prompt, meticulously executed prophylaxis almost always prevents human rabies. The wound is cleansed immediately and thoroughly with soap and water or benzalkonium chloride. Deep puncture wounds are flushed with soapy water using moderate pressure. Wounds are usually left open.
Postexposure prophylaxis (PEP) with rabies vaccine and rabies immune globulin is given depending on the biting animal and circumstances (see Table 1: Brain Infections: Rabies Postexposure Prophylaxis ). PEP is begun, and the animal's brain is tested for virus. Local or state health departments or the Centers for Disease Control and Prevention usually conduct testing and can advise on other treatment issues.
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Table 1
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Rabies Postexposure Prophylaxis
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Animal Type
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Evaluation and Disposition of Animal
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Postexposure Prophylaxis*
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Skunks, raccoons, bats,† foxes, and most other carnivores
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Regarded as rabid unless proved negative by laboratory tests‡
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Consider immediate vaccination
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Dogs, cats, and ferrets
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Healthy and available for 10 days of observation
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Do not begin immunoprophylaxis unless animal develops symptoms of rabies§
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Unknown (escaped)
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Consult public health officials¶
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Rabid or suspected rabid
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Vaccinate immediately
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Livestock, small rodents (eg, squirrels, hamsters, guinea pigs, gerbils, chipmunks, rats, mice), lagomorphs (rabbits and hares), large rodents (woodchucks and beavers), and other mammals
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Consider individually
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Consult public health officials; immunoprophylaxis almost never required for bites of squirrels, hamsters, guinea pigs, gerbils, chipmunks, rats, mice, other small rodents, or lagomorphs
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*Clean all bites immediately with soap and water.
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†Because detecting bat bites is difficult, vaccination is indicated if a bite is reasonably likely, as when a person awakens with a bat in the room or a young child is found with a bat.
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‡The animal should be euthanized and tested as soon as possible. Holding for observation is not recommended. Vaccine is discontinued if rabies immunofluorescence tests of the animal are negative.
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§If the animal remains healthy during the 10-day observation period, it was not infective at the time of bite. However, treatment with rabies immune globulin (RIG) and human diploid cell vaccine (HDCV) or rabies vaccine is begun at the 1st sign of rabies in a dog, cat, or ferret that has bitten someone. A symptomatic animal should be immediately euthanized and tested.
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¶If expert consultation is not available locally and rabies is possible, immediate vaccination should be considered.
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Adapted from “Rabies prevention—United States 1999: Recommendations of the Immunization Practices Advisory Committee (ACIP).” Morbidity and Mortality Weekly Report 48(RR-1):1–21, 1999.
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For PEP, rabies immune globulin (RIG) 20 IU/kg is infiltrated around the wound for passive immunization; if injection volume is too much for distal areas (eg, fingers, nose), some RIG may be given IM. This treatment is accompanied by human diploid cell rabies vaccine (HDCV) for active immunization. HDCV is given in a series of 5 1-mL IM injections (deltoid area is preferred), beginning on the day of exposure (day 0), in a limb other than the one used for RIG. Subsequent injections occur on days 3, 7, 14, and 28. The WHO also recommends a 6th injection on day 90. Rarely, a serious systemic or neuroparalytic reaction occurs; then, completion of vaccination is weighed against the patient's risk of developing rabies. Rabies antibody titer is measured to help assess risk of discontinuing vaccination.
PEP for a person previously vaccinated against rabies includes 1-mL IM injections of HDCV on days 0 and 3 but no RIG.
HDCV is safe and recommended for preexposure prophylaxis for people at risk, including veterinarians, animal handlers, spelunkers, workers who handle the virus, and travelers to endemic areas.
Last full review/revision November 2005
Content last modified November 2005
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