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THE MERCK MANUAL MEDICAL LIBRARY: The Merck Manual of Diagnosis and Therapy
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Infertility is inability of a couple to conceive after 1 yr of unprotected intercourse.

Frequent, unprotected intercourse results in conception for 50% of couples within 3 mo, for 75% within 6 mo, and for 90% within 1 yr. Infertility can be caused by the following:

  • Sperm disorders (35% of couples)
  • Decreased ovarian reserve or ovulatory dysfunction (20%)
  • Tubal dysfunction and pelvic lesions (30%)
  • Abnormal cervical mucus ( 5%)
  • Unidentified factors (10%)

Inability to conceive often leads to feelings of frustration, anger, guilt, resentment, and inadequacy.

Couples wishing to conceive are encouraged to have frequent intercourse for the few days when ovulation is most likely, probably midway between menstrual cycles. Measuring morning basal body temperature (BBT) daily can help determine when ovulation is occurring in women with regular menstrual cycles. A decrease suggests impending ovulation; an increase of 0.5°C suggests ovulation has just occurred. Commercially available luteinizing hormone (LH) prediction test kits, which identify the midcycle LH surge, can also help determine when ovulation occurs and is less disruptive than measuring BBT. Use of caffeine and tobacco, which can impair fertility, is discouraged.

If these measures do not result in pregnancy, a diagnostic evaluation is done. It begins with history, examination, and counseling of both partners. Men are evaluated for sperm disorders, and women for ovulatory and tubal dysfunction and pelvic lesions.

Support groups for couples (eg, American Fertility Association, RESOLVE) may help. If the likelihood of conceiving is low (usually after 2 yr of treatment), the clinician should mention adoption.

Last full review/revision November 2008 by Robert W. Rebar, MD

Content last modified November 2008

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