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(See also Thyroid Disorders.)

Thyroid disorders may predate or develop during pregnancy. Fetal effects vary with the disorder and drugs used for treatment. But generally, hyperthyroidism causes fetal growth restriction and stillbirth, and hypothyroidism causes intellectual deficits in offspring and miscarriage. The most common causes of maternal hypothyroidism are Hashimoto's thyroiditis and treatment of Graves' disease. If women have or have had a thyroid disorder, thyroid status should be closely monitored during and after pregnancy in the women and in the offspring.

Pregnancy does not change the symptoms of hypothyroidism and hyperthyroidism or the normal values and ranges of free serum thyroxine (T₄) and thyroid-stimulating hormone (TSH).

Graves' disease: Maternal Graves' disease is monitored clinically and with free T₄ and high-sensitivity TSH assays. Treatment varies. Usually, pregnant women are given the lowest possible dose of oral propylthiouracil Some Trade Names
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(50 to 100 mg q 8 h). Therapeutic response occurs over 3 to 4 wk; then the dose is changed if needed. Propylthiouracil Some Trade Names
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crosses the placenta and may cause goiter and hypothyroidism in the fetus. Simultaneous use of l-thyroxine or l-triiodothyronine is contraindicated because these hormones may mask the effects of excessive propylthiouracil Some Trade Names
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in pregnant women and result in hypothyroidism in the fetus. Methimazole Some Trade Names
TAPAZOLE
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is an alternative to propylthiouracil Some Trade Names
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. Graves' disease commonly improves during the 3rd trimester, often allowing dose reduction or discontinuation of the drug. Although very uncommon, in centers with experienced thyroid surgeons, a 2nd-trimester thyroidectomy may be considered after drug treatment restores euthyroidism. After thyroidectomy, women are given full replacement of l-thyroxine (0.15 to 0.2 mg/day), beginning 24 h later. Radioactive iodine (diagnostic or therapeutic) and iodide solutions are contraindicated during pregnancy because of adverse effects on the fetal thyroid gland. β-Blockers are used only for thyroid storm or severe maternal symptoms.

If pregnant women have or have had Graves' disease, fetal hyperthyroidism may develop. Whether these women are clinically euthyroid, hyperthyroid, or hypothyroid, thyroid-stimulating immunoglobulins (Igs) and thyroid-blocking Igs (if present) cross the placenta. Fetal thyroid function reflects the relative fetal levels of these stimulating and blocking Igs. Hyperthyroidism can cause fetal tachycardia (> 160 beats/min), growth restriction, and goiter, which can lead to decreased fetal swallowing, polyhydramnios, and preterm labor. Ultrasonography is used to evaluate fetal growth, thyroid gland, and heart.

Congenital Graves' disease: If pregnant women have taken propylthiouracil Some Trade Names
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, congenital Graves' disease in the fetus may be masked until 7 to 10 days after birth, when the drug's effect subsides.

Maternal hypothyroidism: Women with mild to moderate hypothyroidism frequently have normal menstrual cycles and can become pregnant. During pregnancy, the usual dose of l-thyroxine is continued. As pregnancy progresses, minor dose adjustments may be necessary, ideally based on TSH measurement after several weeks. If hypothyroidism is first diagnosed during pregnancy, l-thyroxine is started at 0.1 mg po once/day.

Hashimoto's thyroiditis: Maternal immune suppression during pregnancy often ameliorates chronic thyroiditis; however, hypothyroidism or hyperthyroidism that requires treatment sometimes develops.

Acute (subacute) thyroiditis: Common during pregnancy, this disorder usually produces a tender goiter during or after a respiratory infection. Transient, symptomatic hyperthyroidism with elevated T₄ can occur, often resulting in misdiagnosis as Graves' disease. Usually, treatment is unnecessary.

Postpartum maternal thyroid dysfunction: Hypothyroid or hyperthyroid dysfunction occurs in 4 to 7% of women during the 1st 6 mo after delivery. Incidence seems to be higher among pregnant women with a goiter, Hashimoto's thyroiditis, a strong family history of autoimmune thyroid disorders, or type 1 ( insulin Some Trade Names
HUMULIN
NOVOLIN
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-dependent) diabetes mellitus. In women with any of these risk factors, TSH and free serum T₄ levels should be checked in the 1st trimester and postpartum. Dysfunction is usually transient but may require treatment. After delivery, Graves' disease may recur transiently or persistently.

Painless thyroiditis with transient hyperthyroidism is a recently recognized postpartum, probably autoimmune, disorder. It develops abruptly in the 1st few weeks postpartum, results in a low radioactive iodine uptake, and is characterized by lymphocytic infiltration. Diagnosis is by symptoms, thyroid function tests, and by exclusion of other conditions. This disorder may persist, recur transiently, or progress.

Last full review/revision November 2005

Content last modified November 2005