Individualized neoantigen therapies: exploring one medicine for one patient
Scientists are researching new ways to help train the immune system to fight cancer
April 13, 2023
Share this article
youtube
https://www.youtube.com/watch?v=JueUy8zw2UM
:
Over the past decade, immunotherapy has transformed our understanding of how the immune system can be used to help fight some types of cancer. However, for the last 50 years, scientists have been researching how we could potentially use vaccines to treat cancer — another investigational approach to harness the immune system to help recognize and destroy cancer cells — with little success.
Now we’re looking at a potential therapy that is building upon the learnings of immunotherapy trials from the past and incorporating that into an individualized cancer approach that’s specific to a patient’s own tumor. Researchers are currently exploring the potential of individualized neoantigen therapies to help fight cancer.
Cancer research is becoming more personalized
Cancer is a result of the body’s own cells undergoing mutations which create abnormal proteins in cancer cells, known as neoantigens, that are not usually seen in normal cells. These mutations are unique to each person’s tumor, so that’s one of the reasons why patients who have been diagnosed with the same type of cancer and who have received the same type of treatment may have different responses.
As the treatment of cancer continues to evolve and advance, researchers are focusing on more individualized approaches. This includes a new area of research into individualized neoantigen therapies that use information from a person’s tumor biopsy sample to help develop a therapy unique to their tumor’s mutations.
“This area of research has really captured our imagination of what’s possible in the development of cancer therapeutics.”
Dr. Jane Healy Vice president and head of oncology early development at Merck Research Laboratories
In collaboration with Moderna, we’re studying this area of research in an effort to advance more individualized approaches to help improve outcomes for people living with cancer.
Learn more about individualized neoantigen therapies
The American Chemical Society Landmark program recognizes important contributions to modern life through chemical sciences
March 2, 2023
Share this article
Scientific achievements can significantly alter the course of history — for individuals, families and communities as well as for future scientific developments. We’re proud to have been recognized for our own contributions to science by the American Chemical Society (ACS), which has granted Merck four National Historic Chemical Landmarks (NHCL) designations since 1999.
This ACS program recognizes seminal achievements in the history of the chemical sciences and provides a record of the contributions to chemistry and society in the U.S. Our Rahway, New Jersey, site has been recognized three times. Our West Point, Pennsylvania, site has been recognized once for our important work there.
Learn more about these groundbreaking landmark achievements:
01.
Discovery and development of medicines for the treatment of HIV
In the early 1980s, as AIDS began to be perceived as a potential epidemic, scientists at Merck embarked on an urgent mission to understand the virus. They were among the first to discover and develop medicines for the treatment of HIV. Our company’s work in this space ultimately led to the development of a treatment that was important in helping to make HIV a survivable infection.
ACS honored the discovery of this life-saving treatment with the NHCL designation in 2022 at our site in West Point, Pennsylvania.
Development of a treatment against a debilitating infectious disease transmitted by parasites
Transmitted through the bite of black flies — which live and breed near fast-flowing streams and rivers — river blindness (onchocerciasis) is one of the leading causes of preventable blindness worldwide. In 1978, Dr. William Campbell of Merck Research Laboratories suggested the use of Mectizan (ivermectin) against river blindness in humans. In the early 1980s, Dr. Mohammed Aziz collaborated with WHO to successfully design and implement field studies in West Africa on the disease.
In 1987, Merck CEO Dr. Roy Vagelos announced our company’s commitment to donate Mectizan to treat river blindness — as much as needed, for as long as needed — and the Mectizan Donation Program was formed. Through the MDP, the work of Dr. Campbell and other Merck scientists continues to touch more than 300 million lives each year. In 2015, Dr. Campbell shared the Nobel Prize in Physiology or Medicine for his role in developing ivermectin.
ACS honored the discovery of ivermectin with the NHCL designation in 2016 at our site in Rahway, New Jersey.
Addressing vitamin deficiencies through the synthesis and mass production of vitamin B
In the 1930s and 1940s, Merck scientists reported a series of advances in the study of the vitamin B complex, a group of nutrients that is essential to cell functioning. Availability of these vitamins resulted in dietary supplements and vitamin-enriched foods that encouraged healthy growth and development, as well as treatments for diseases caused by nutritional deficiencies.
These achievements were outstanding examples of the rapid advances occurring in the fields of biochemistry and organic chemistry during this era and led to notable improvements in human and animal health and nutrition.
ACS honored our research on the vitamin B complex with the NHCL designation in 2016 at our site in Rahway, New Jersey.
04.
Producing large-scale quantities of penicillin, a much-needed antibiotic during WWII
Alexander Fleming discovered penicillin in 1928, but it was very difficult to produce in large quantities. With the outbreak of World War II, the need for life-saving penicillin skyrocketed, and the mass production problem had to be solved quickly. At the request of the U.S. government, Merck and other pharmaceutical companies expanded research in the hopes of producing adequate supplies of this vital antibiotic. In cooperation with competitors, our research team helped develop a submerged fermentation process that sped production of penicillin for both the war effort and civilian use.
ACS honored the discovery of this life-saving treatment with the NHCL designation in 1999 at our site in Rahway, New Jersey.
Our history
For over 130 years, we’ve been guided by the view that great medicines and vaccines change the world.
“We try never to forget that medicine is for the people. It is not for the profits.”
Proteins in space: taking our research to the final frontier
Merck Research Laboratories scientist Paul Reichert works with the International Space Station to drive innovation
June 29, 2022
Share this article
Merck Research Laboratories (MRL) is known for pushing the frontiers of science with its cutting-edge research. And MRL scientist Paul Reichert has taken that concept even further — to space!
Reichert was one of the first scientists in the pharmaceutical industry to propose studying protein crystallization under microgravity conditions, and his work continues today.
“We regularly use crystallization processes for our small molecule and small protein therapeutics. Our goal with these experiments is to identify crystallization processes for biologics for enhanced and simpler drug delivery,” explained Reichert.
Experimental conditions in microgravity are unique because without the force of Earth’s gravity, solutions have reduced convection currents, reduced sedimentation and reduced molecular motion, leading to higher-order crystals with higher purity and more uniform suspensions. Researchers have been able to apply this knowledge ‘on the ground’ by manipulating key variables to mimic those in microgravity, such as using rotational mixers to reduce sedimentation.
Paul Reichert (L) joins April Spinale and Raymond Polniak of the ISS National Laboratory, managed by the Center for the Advancement of Science in Space, Inc. (CASIS), to inspect the experiment
The latest MRL experiment blasted off to the International Space Station in December with astronaut Marc Vande Hei completing the experiment designed to study the effects of purity, mixing, diffusion and temperature on crystallization. Simultaneously, back on Earth, a research team was doing a control experiment in a laboratory for comparison. Reichert is now working alongside other MRL scientists to analyze and compare the results of the experiment run in space against the ground experiment done under the same conditions with gravity.
“I feel so fortunate to have been able to push the frontiers of science with amazing scientists here at Merck and at the ISS National Laboratory. It’s been the highlight of my career.”
Paul Reichert Associate principal scientist, structural chemistry
Creating a new world in Minecraft for students to explore
Periodic Odyssey
November 8, 2021
Share this article
brightcove
https://www.youtube.com/watch?v=8KEkME5gi54
1611106632001:6280946306001
Our passion for invention isn’t limited to the health care industry and the patients we serve; it drives us to inspire the next generation of inventors. So, we created a new approach to science-based learning.
Periodic Odyssey is a new world in Minecraft where students explore, search for and find elements from the periodic table and unlock the power of science with special in-game rewards.
Using the game’s traditional pickaxe and custom element-inspired skins, players will explore our completely unique, immersive Minecraft map to hunt for all naturally-occurring elements.
After bringing the elements back to the science lab, they’ll see the fruits of their labor, amassing the collection of found elements, unlocking sections of the lab by doing so, and being rewarded with special tools to help with their search as the rarer elements become more challenging to find. It all adds up to make screen time into learning time, and to spark inspiration in budding scientists.
This new map will be available in both Minecraft: Education Edition, for use in classrooms, and Minecraft, open to all players all over the world.
Our hope is that we can foster an interest in the sciences among young people that will lead to a future full of invention.
"Periodic Odyssey has the potential to increase student familiarity with both those elements (and symbols) met in a typical school curriculum as well as those, such as the rare earth elements, that are integral to modern life."
Forward-looking statement of Merck & Co., Inc., Rahway, N.J., USA
This website of Merck & Co., Inc., Rahway, N.J., USA (the “company”) includes “forward-looking statements” within the meaning of the safe harbor provisions of the U.S. Private Securities Litigation Reform Act of 1995. These statements are based upon the current beliefs and expectations of the company’s management and are subject to significant risks and uncertainties. There can be no guarantees with respect to pipeline candidates that the candidates will receive the necessary regulatory approvals or that they will prove to be commercially successful. If underlying assumptions prove inaccurate or risks or uncertainties materialize, actual results may differ materially from those set forth in the forward-looking statements.
Risks and uncertainties include but are not limited to, general industry conditions and competition; general economic factors, including interest rate and currency exchange rate fluctuations; the impact of pharmaceutical industry regulation and health care legislation in the United States and internationally; global trends toward health care cost containment; technological advances, new products and patents attained by competitors; challenges inherent in new product development, including obtaining regulatory approval; the company’s ability to accurately predict future market conditions; manufacturing difficulties or delays; financial instability of international economies and sovereign risk; dependence on the effectiveness of the company’s patents and other protections for innovative products; and the exposure to litigation, including patent litigation, and/or regulatory actions.
The company undertakes no obligation to publicly update any forward-looking statement, whether as a result of new information, future events or otherwise. Additional factors that could cause results to differ materially from those described in the forward-looking statements can be found in the company’s Annual Report on Form 10-K for the year ended December 31, 2024 and the company’s other filings with the Securities and Exchange Commission (SEC) available at the SEC’s Internet site (www.sec.gov).
No Duty to Update
The information contained in this website was current as of the date presented. The company assumes no duty to update the information to reflect subsequent developments. Consequently, the company will not update the information contained in the website and investors should not rely upon the information as current or accurate after the presentation date.
