Data from Merck’s Investigational Hepatitis C Treatment Portfolio to be Presented at the 64th American Association for the Study of Liver Diseases Annual Meeting
October 1, 2013 9:00 am ET
Merck (NYSE:MRK), known as MSD outside the United States and Canada,
today announced the presentation of data from studies evaluating the
company’s investigational oral chronic hepatitis C virus (HCV)
treatments MK-5172 and MK-8742 at the 64th American
Association for the Study of Liver Diseases Annual Meeting (AASLD). The
meeting is scheduled to take place in Washington, D.C., Nov. 1-5, 2013.
“Merck is committed to developing HCV therapies that have the potential
to offer new options for a broad range of patient types,” said Dr. Eliav
Barr, vice president, Infectious Diseases, Merck Research Laboratories.
“We continue to build upon our strong legacy in HCV and look forward to
sharing the latest clinical data for our investigational HCV therapies,
MK-5172 and MK-8742.”
MK-5172 is an investigational, once-daily, oral HCV NS3/4A protease
inhibitor currently in Phase IIB development. MK-8742 is an
investigational, once-daily, oral HCV NS5A replication complex inhibitor
currently in Phase IIB development. Both candidates are being evaluated
in broad clinical programs that include investigations in various HCV
segments, multiple HCV genotypes and patients who have previously failed
Selected presentations of clinical data for MK-5172 and MK-8742
High Efficacy and Safety of the All-Oral Combination Regimen,
MK-5172/MK-8742 +/- RBV for 12 Weeks in HCV Genotype 1 Infected
Patients: The C-WORTHY Study. Lawitz, E., et al. Oral Presentation
#76: Sunday, Nov. 3, 2013, 5:30-5:45 p.m.
Kinetic Analyses of Antiviral Suppression by NS5A Inhibitors Reveal
Early and Potent Inhibition of Viral Assembly and Release. McGivern,
D.R., et al. Oral Presentation #78: Sunday, Nov. 3, 2013, 6:00-6:15
High Efficacy at Lower Doses of MK-5172 25mg and 50mg Daily for 12
weeks in HCV Genotype (G) 1 Treatment-Naïve Non-Cirrhotic Patients.
Vierling, J., N et al. Poster #1123. Sunday, Nov. 3, 2013, 8:00 a.m.
to 5:30 p.m.
Efficacy and Safety of an Interferon-Free Regimen of MK-5172 +
Ribavirin for 12 Weeks or 24 Weeks in Treatment-Naïve, Non-Cirrhotic
Subjects with HCV GT1 Infection: The C-SPIRIT Study. Gane, E.J., et
al., Poster #1110. Sunday, Nov. 3, 2013, 8:00 a.m. to 5:30 p.m.
MK-8742, a HCV NS5A Inhibitor with a Broad Spectrum of HCV Genotypic
Activity, Demonstrates Potent Antiviral Activity in Genotype-1 and -3
HCV-Infected Patients. Yeh, W. W., et al. Poster #479. Saturday, Nov.
2, 2013, 2:00-7:30 p.m.
The abstracts were published today and can be accessed on the AASLD
website. For program information, please visit: http://www.aasld.org/livermeeting/program/Pages/default.aspx
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