Data on Vericiguat, Investigational Heart Failure Medicine, to be Presented as Late-Breaking Clinical Trial at the 2015 American Heart Association (AHA) Scientific Sessions
November 6, 2015 9:31 am ET
Vericiguat study in patients with worsening chronic heart failure and reduced ejection fraction (HFrEF)
Whippany, N.J. and Kenilworth, N.J. – Bayer and Merck (NYSE:MRK), known as MSD outside the United States and Canada, announced today that new data on vericiguat (BAY 1021189), an investigational oral sGC (soluble guanylate cyclase) stimulator being co-developed by Bayer and Merck for chronic heart failure and reduced left ventricular ejection fraction (HFrEF), will be presented at the upcoming American Heart Association (AHA) Scientific Sessions to be held November 7 to November 11, 2015 in Orlando, Florida. The data were accepted as a late-breaking clinical trial presentation and are the results of the Phase IIb SOCRATES-REDUCED study. The objective of the study was to investigate the change over 12 weeks in NT-pro BNP (a blood marker of heart failure) to determine the appropriate dose of vericiguat for consideration in a Phase III clinical trial in patients with chronic HFrEF in addition to standard therapy.
The following data will be presented at AHA Scientific Sessions 2015:
Vericiguat Data Analysis
- Oral sGC stimulator Vericiguat in patients with worsening chronic heart failure and reduced ejection fraction – The SOluble guanylate Cyclase stimulatoR in heArT failurE patientS with REDUCED EF (SOCRATES-REDUCED) Study
- Sunday, November 8: 4:13 PM-4:22 PM ET. Session: LBCT.01 – Failure is Not an Option: New Drugs and Systems of Care. Location: Orange County Convention Center, Hall D
“Of the millions who suffer from heart failure, approximately half are estimated to have heart failure with reduced ejection fraction,” said Dr. Daniel Bloomfield, vice president, Cardiovascular Diseases, Merck Research Laboratories. “As a company, we feel it’s important to research additional treatment options for this disease.”
“Heart failure with reduced ejection fraction is an area of unmet need,” said Dario Mirski, MD, vice president of U.S. medical affairs, Bayer Pharmaceuticals. “At Bayer we’re committed to researching and advancing new therapies to help people with this condition.”
Vericiguat is part of a worldwide development collaboration between Merck and Bayer in the field of sGC modulation, which seeks to target a distinct molecular mechanism that is associated with the underlying pathophysiology of heart failure. The soluble guanylate cyclase (sGC) enzyme, which is important for the function of both the blood vessels and the heart, is insufficiently stimulated in heart failure due to impaired NO (nitric oxide) availability and endothelial dysfunction.
About Worldwide Collaboration between Merck and Bayer
The global collaboration between Merck and Bayer brings together two leaders in the field of sGC research and uses the capabilities and resources of both companies.
About Heart Failure with Reduced Ejection Fraction (HFrEF)
HFrEF, formerly known as systolic heart failure, is characterized by the compromised ability of the heart to eject blood sufficiently during its contraction phase. HFrEF is a final common pathway for many cardiovascular diseases, including coronary artery disease. Once established, HFrEF often progresses due to activation of a variety of pathways such as the renin-angiotensin-aldosterone system (RAAS) that adversely affect cardiac structure and function.
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