Merck Highlights Data Presentations at the Alzheimer’s Association International Conference, 2012


July 13, 2012 4:00 pm ET

Merck (NYSE: MRK), known as MSD outside the United States and Canada,
announced today presentations at the upcoming Alzheimer’s Association
International Conference (AAIC) being held in Vancouver, British
Columbia, Canada on July 14-19, 2012. At the conference, Merck
scientists are scheduled to present results from multiple preclinical
and clinical studies investigating the safety and efficacy of β-amyloid
precursor protein site cleaving enzyme (BACE) inhibitors, including
MK-8931, the company’s lead compound currently being investigated as a
potential treatment for Alzheimer’s disease.

“The prevalence of Alzheimer’s disease is growing rapidly due to the
aging population, creating an unsustainable burden on patients,
caregivers and the economy,” said Darryle D. Schoepp, Ph.D., senior vice
president and head of Neuroscience and Ophthalmology franchise, Merck
Research Laboratories. “Merck is committed to discovering and developing
novel medicines to treat neurodegenerative brain diseases, such as
Alzheimer’s and dementia, and is focused on rapidly advancing its BACE
inhibitor program.”

Select Merck presentations at AAIC include:

July 15, 2012

  • P1-221: Safety and pharmacokinetics of the novel BACE inhibitor
    MK-8931 in healthy subjects following single and multiple dose
  • P1-225: A study to evaluate the pharmacokinetics and
    pharmacodynamics of single and multiple oral doses of the novel BACE
    inhibitor MK-8931 in Japanese subjects.
  • P1-229: Population pharmacokinetic modeling of the novel
    BACE inhibitor MK-8931 following single and multiple dose
    administration in healthy subjects.

July 18, 2012

  • P4-196: The novel BACE inhibitor MK-8931 dramatically lowers
    CSF Abeta peptides in healthy subjects following single and multiple
    dose administration.

Earlier this year, Merck disclosed the results of a two part randomized,
double-blind, placebo-controlled single dose study evaluating the safety
and tolerability of MK-8931 in 40 healthy adults 18 to 45 years of age.
Single doses of MK-8931 were associated with marked reductions in
amyloid beta peptide concentration levels with a mean reduction from
baseline of up to 92 percent. MK-8931 was generally well tolerated in
these healthy subjects with no serious adverse events and no study
discontinuations. Adverse events were generally mild to moderate in
intensity and transient in duration and included headache (57 percent
and 50 percent), nasal congestion (23 percent and 30 percent) and
dizziness (20 percent and 40 percent, for MK-8931 and placebo

About BACE

The amyloid hypothesis predicts that abnormal accumulation of amyloid-β
peptide is a central event in the progression of Alzheimer’s disease.
The enzyme BACE is a key enzyme in the initiation of synthesis of
amyloid β peptide. Inhibition of BACE is therefore believed to provide a
promising means for therapeutic intervention in Alzheimer’s disease.

About Merck

Today’s Merck is a global healthcare leader working to help the world be
well. Merck is known as MSD outside the United States and Canada.
Through our prescription medicines, vaccines, biologic therapies, and
consumer care and animal health products, we work with customers and
operate in more than 140 countries to deliver innovative health
solutions. We also demonstrate our commitment to increasing access to
healthcare through far-reaching policies, programs and partnerships. For
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Ian McConnell, 908-423-3046
Carol Ferguson, 908-423-4465

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