Innovation

Our Q3 2024 financial results

October 31, 2024

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Merck’s (NYSE: MRK) Q3 2024 financial results represent strong progress across the business and our diverse pipeline. Our company announced worldwide sales of $16.7 billion, an increase of 4% from Q3 2023.

“Our third-quarter results were strong, as we continue to make progress heading into 2025 and beyond,” said Rob Davis, chairman and chief executive officer. “Our pipeline is advancing and expanding, demonstrating our success in creating a sustainable innovation engine, and positioning Merck with a more diversified portfolio to drive growth. I continue to remain confident in the strength of our business and our ability to execute, and I want to thank our colleagues across the globe for their focus and commitment as we work to create lasting value for patients, shareholders and all our stakeholders.”

Merck anticipates full-year 2024 worldwide sales to be between $63.6 billion and $64.1 billion.

Find more details on Q3 2024 results below.

q3 2024 earning

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Health awareness

Learn more about invasive pneumococcal disease and how infection spreads

Invasive pneumococcal disease can lead to a number of serious consequences in children

October 25, 2024

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What is invasive pneumococcal disease?

Invasive pneumococcal disease (IPD) is an infection caused by a bacteria called Streptococcus pneumoniae. It can lead to a number of serious illnesses including pneumococcal bacteremia (an infection of the blood) and pneumococcal meningitis (an infection of the coverings of the brain and spinal cord). 

Children under the age of 2 and those with certain underlying medical conditions are particularly vulnerable to invasive pneumococcal disease, according to the Centers for Disease Control and Prevention (CDC). 

~100

different types of S. pneumoniae, called serotypes, exist; however, a smaller number are responsible for most cases of IPD in children

~1 in 4

cases of IPD in children under 5 years of age were caused by serotypes 3, 22F and 33F, according to a pooled analysis from 2018-2021

How does pneumococcal infection spread?

Pneumococcal bacteria can spread anywhere, anytime through close contact with respiratory secretions, like those produced from coughing or sneezing. Children can carry the bacteria in their nose or throat without demonstrating signs of illness. 

Pneumococcal infections are more common during winter and early spring when respiratory diseases are more prevalent.

What you can ask your pediatrician about pneumococcal infection:

  • Is my child at risk for invasive pneumococcal disease?
  • How could invasive pneumococcal disease harm my child?
  • What can I do to help reduce the risk of invasive pneumococcal disease for my child?

“There are steps people can take to be proactive about their family’s health. Parents should speak with their health care providers to learn more about invasive pneumococcal disease and the serious consequences it can cause.”

  • Dr. Ulrike Buchwald, scientific associate vice president, clinical research
Innovation

TL1A: Exploring a potentially important target for inflammatory bowel disease

Our scientists are investigating ways to modulate TL1A to potentially address inflammation and fibrosis associated with inflammatory bowel disease

October 9, 2024

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TL1A diagram

Picture the immune system as a carefully orchestrated network of organs, cells and molecules working together to protect your body from foreign invaders. Normally, this system operates smoothly, identifying and then fighting off microbes. However, in the case of inflammatory bowel disease (IBD), a person’s immune system can mistakenly attack their own tissues, causing chronic inflammation and tissue damage.

Nearly three million people in the U.S. live with Crohn’s disease or ulcerative colitis, the two most common forms of IBD. Patients with IBD experience symptoms such as diarrhea, blood in the stool, abdominal pain, unintended weight loss, fatigue and impaired sleep. In 25-40% of patients, IBD may affect organs and tissues outside of the gastrointestinal system, including the joints, skin, bones, eyes, kidneys and liver. When IBD is uncontrolled, it can lead to hospitalizations and surgery.

Despite available therapies which have helped improve patients’ symptoms over the last two decades, many patients do not achieve a state of sustained remission.  

“People with IBD often struggle to find a treatment that works for them because each individual’s disease is different,” said Aileen Pangan, vice president and therapeutic area head, immunology clinical research, Merck Research Laboratories.

“With a better understanding of the biology of IBD, medicines have begun to emerge that aim to change the way we approach treatment. We’re investigating ways to modulate targets, including TL1A, that have been implicated in IBD and other immune-mediated inflammatory diseases.”

  • Aileen Pangan

Our TL1A research

Our scientists are investigating tumor necrosis factor-like ligand 1A (TL1A), which has been shown to be increased in inflamed intestinal tissue and in the systemic circulation of patients with IBD.

TL1A is a cytokine, a protein functioning as a chemical messenger, that acts as a regulator of cellular immunity. In healthy people, levels of TL1A increase to help immune cells fight infections effectively, with levels going back down after the infection is gone. However, in IBD, TL1A levels are chronically elevated, leading to an excessive buildup of immune cells in the digestive tract, chronic inflammation, tissue damage and fibrosis.

Teams at Merck are evaluating the potential role of TL1A across immune-mediated inflammatory diseases, including Crohn’s disease, ulcerative colitis and systemic sclerosis-associated interstitial lung disease (SSc-ILD). Learn more about our research in immunology.

Health awareness

Driving prostate cancer research forward

Our scientists are dedicated to advancing research for potential treatment options for people diagnosed with prostate cancer

September 4, 2024

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It’s estimated that nearly 1.5 million people assigned male at birth were diagnosed with prostate cancer in 2022 worldwide.

But these patients aren’t just a statistic or a number. They’re our partners, our parents, our children, our siblings and our friends. They’re our loved ones, fighting for better outcomes and a chance for the future. And that’s who we’re fighting for, too.

“Globally, someone is diagnosed with prostate cancer nearly every minute. That’s why we’re working with urgency to advance research and provide potential treatment options for patients living with this disease.”

  • Dr. Kentaro Imai, distinguished scientist, oncology, prostate clinical research

The impact of prostate cancer on patients

Prostate cancer is the second most commonly diagnosed cancer and the fifth leading cause of cancer death in patients assigned male at birth worldwide. The average age at diagnosis is 66 years old. Prostate cancers is more likely to develop among those with African ancestry or a family history of the disease.

Prostate cancer can be genetic in other ways, too. Several inherited genetic mutations — such as those of the BRCA1 or BRCA2 genes — can increase prostate cancer risk. These types of genetic mutations, among others, can be identified through testing your tumor (also known as biomarker testing).

For those patients who are diagnosed with early stage prostate cancer, the prognosis is promising, with a five-year survival rate of nearly 100%. However, for patients with prostate cancer at an advanced stage, the outcomes can be dramatically different, and the five-year survival rate remains low.

“As with many cancers, patients with prostate cancer have the greatest chance of survival when their disease is detected early,” said Dr. Imai. “The prognosis for prostate cancer worsens as it spreads to other areas of the body, given that there are limited treatment options at that stage. It’s critical that we push forward to identify new options for these patients.”

Our commitment to prostate cancer research

Our science, coupled with new insights into the disease, continues to guide us as we pursue clinical advancements in prostate cancer.

Dr_KentaroImai

"Our scientists are working diligently each and every day in an effort to discover new solutions for patients with prostate cancer."

— Dr. Kentaro Imai

Distinguished scientist, oncology, prostate clinical research

Since the next breakthrough can come from anywhere or anyone, we regularly collaborate across the entire prostate cancer community, working with health care providers, other companies, academia and advocates to gain a deeper understanding and make progress for patients with prostate cancer.

“The fight against prostate cancer is constantly evolving, and therefore our approach to the disease must evolve, as well,” said Dr. Imai. “We’re committed to pushing boundaries in pursuit of breakthrough advances that have the potential to change the lives of patients living with prostate cancer.”

Health awareness

Understanding lung cancer: 5 essential things to know as a patient or caregiver

What to know about one of the most common types of cancer

August 21, 2024

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Lung cancer is one of the most commonly diagnosed cancers worldwide. In 2022, it was estimated that more than 2.4 million people globally were diagnosed with lung cancer.

Lung cancer is also the leading cause of cancer death worldwide. Nearly one-in-five (19%) cancer-related deaths were estimated to result from the disease worldwide in 2022.

Despite how common lung cancer is and its high mortality rates, there are still many misconceptions about the disease. Having accurate information is a critical step in the fight against lung cancer.

Our company is working for these patients and their families by advancing research and fostering greater awareness and understanding of the disease.

Here are five facts about lung cancer that we think patients or caregivers need to know.

01.

Every person with lung cancer deserves compassion and support.

People with lung cancer can face social stigma because they may have smoked. But the truth is, there’s no room for blame. People with lung cancer are worthy of all the compassion and support their families, health care teams and the wider cancer community can provide to help them stand against this disease.

Caregiver holding patient's hand

02.

It takes a village to navigate life with lung cancer.

When coping with a lung cancer diagnosis, it’s important to build a circle of support that includes the oncologist, health care teams, family and friends.

Connecting with others can provide a sense of support and comfort to help patients through everything that goes into managing this disease.

03.

There’s no one type of person who develops lung cancer.

Lung cancer strikes both men and women. While it is mostly diagnosed in older people, younger people can develop the disease. In fact, in 2022, more than 312,000 cases of lung cancer were estimated to be diagnosed worldwide among people 54 and younger.

Crowded street downtown

04.

There are multiple risk factors for lung cancer, including some outside our control.

Smoking is the greatest risk factor for developing lung cancer, but there are others as well, including having a family history of the disease and exposure to certain environmental substances. Worldwide, it is estimated that 10-25% of patients with lung cancer have never smoked with even higher proportions based on ethnicity and geographic region.

Environmental risks include:

  • Exposure to radon gas.
  • Exposure to occupational carcinogens, such as asbestos.
  • Exposure to outdoor air pollution, such as second-hand smoke, arsenic, chromium and nickel.

05.

Scientific advances are helping to make an impact in treating lung cancer.

Over the last 20 years, significant strides have been made to improve patient outcomes in the treatment of lung cancer. Key advancements include the development of targeted therapies, the incorporation of biomarker testing into standard practice and the progress of research that may offer promising breakthroughs for patients with difficult-to-treat tumor types.

Sustainability

Merck publishes 2023/2024 Impact Report

Letter from our chairman and chief executive officer, Rob Davis

August 16, 2024

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Rob Davis

Dear Stakeholders,

For more than a century, we’ve been devoted to innovative scientific discovery, delivering medicines and vaccines to address critical health needs, optimizing the efficiency of our supply chain, increasing diversity in clinical trials, evolving our Merck Manual for medical reference and so much more. Importantly, everything we do is inspired by our purpose — to save and improve the lives of people and animals around the world. By harnessing leading-edge science, we’ve tackled some of the world’s biggest health challenges for generations, and we remain committed to expanding access to life-changing medicines, vaccines and technologies for many more decades to come. Operating our business responsibly and sustainably is at the core of our values and foundational to our ways of working and business operations.

To help propel our purpose, we continue to prioritize our ambitious sustainability goals, which span four key focus areas: 1) Access to Health; 2) Employees; 3) Environmental Sustainability and 4) Ethics & Values.

Over the last year, our concerted focus on innovation, collaboration and delivering significant and sustained stakeholder value has driven remarkable progress and impactful outcomes. To these ends, I’m proud to share the following key accomplishments:

Expanding and enabling access to health

Enabling access to health underpins every action we take and every decision we make. Across our enterprise, we collaborate with global partners and stakeholders to advance our scientific discoveries, expand and enable access to our medicines and vaccines, and implement initiatives that drive health equity. In 2023, we reached more than 550 million people with our medicines and vaccines through commercial channels, clinical trials, voluntary licensing and product donations. These critical efforts include our MECTIZAN® Donation Program, the longest-running disease-specific drug donation effort of its kind, which aims to combat river blindness and lymphatic filariasis and reached approximately 385 million people last year.

In 2023, we also expanded on our 2021 access to health ambition, and now have a new goal to enable 350 million more people to access our medicines and vaccines by 2025. In 2023 alone, our efforts enabled access for 240 million people. Our products were delivered to nearly 80% of countries globally. And through our social investments, including partnerships to advance access to health and other impact initiatives, we reached more than 54 million people in low- and middle-income countries and populations underserved by health care in high-income countries, surpassing our goal of reaching more than 50 million people by 2025.

Developing and rewarding an inclusive and healthy workforce

We believe the best path to value creation is through our talent, and the variety of backgrounds and ideas they bring are central to the success of our company. Diversity and inclusion is a business imperative. It improves our understanding of our customers, promotes inclusion in our clinical trials and inspires the innovation that drives our business. We remain committed to actively cultivating a talented and inclusive workforce that best represents—and can thus best serve—our customers, health care providers and patients.

In 2023, we defined and introduced 15 new enterprise leadership skills, designed to further advance our culture, power organizational and individual performance, and drive value for our stakeholders and communities.

Embodying and prioritizing environmental stewardship

We know the global health of people and animals is inextricably linked to the health of the planet. This is why we are committed to playing an active role in mitigating the impacts of climate change. Notably, in 2024, we committed to be net-zero across Scopes 1, 2 and 3 greenhouse gas emissions by 2045, aligned with guidance from the Science Based Targets initiative.

Our environmental sustainability strategy is designed to achieve our objectives by focusing on three critical areas: operational efficiency, designing new products to minimize environmental impact and reducing the impacts in our upstream and downstream value chain. And we have been recognized with six consecutive Green Chemistry Challenge Awards—nine overall—as a result of our ongoing efforts to minimize the footprint of our products. The awards are sponsored by the Environmental Protection Agency and the American Chemistry Society and recognize new and innovative environmentally conscious chemistry technologies.

Holding ourselves to the highest standards

We operate responsibly every day in every way, and we hold ourselves accountable to the highest standards of ethics and values. Our code of conduct is our compass, ensuring we maintain our reputation as a trusted, credible and responsible company. It also encourages employees to speak up and report potential concerns to ensure our ethics and values are reflected in our business operations. We maintain full compliance with all privacy and data regulatory requirements related to active incident monitoring, risk/harm analysis and on-time notification of data breaches.

We are also a signatory to the United Nations Global Compact (UNGC), and we align our operations with the Ten Principles of the UNGC to improve communities around the globe.

Additionally, we increased our spend with small and diverse Tier 1 and 2 suppliers from $3.2 billion in 2022 to $3.6 billion in 2023, fostering a healthy, equitable and diverse supply chain.

In 2023, we also added sustainability metrics to our Company Scorecard, which directly correlates to our annual incentive plan. The metrics link the compensation for most employees, including executives, to our performance in driving greater access to health care and employee engagement and inclusion. And I’m pleased to report that, in our inaugural year, we achieved all of our goals for these new sustainability metrics on our Company Scorecard.

Sustaining our momentum

I am very proud of our collective progress and the positive impact we’ve made on the lives of people, animals and communities around the world. In 2023, Merck was named one of the Top 100 Most Sustainable U.S. Companies by Barron’s and one of America’s Most JUST Companies by JUST Capital and CNBC. And notably, we ranked No. 1 in the health sector for both recognitions. This year, we were also recognized on TIME’s inaugural list of the World’s Most Sustainable Companies, ranking No. 28 out of 500 companies. These honors are a testament to our unwavering passion and commitment to saving and improving lives globally.

I remain confident that we can do even more to further advance global health and access, drive diversity and inclusivity, protect the environment and operate responsibly. I’m excited and energized by the possibilities of our science-led strategy, the promise that our short- and long-term efforts present, and the positive, sustainable impacts that we can make today and well into the future.

My sincerest thanks for your continued support as we pursue a healthier and brighter future for all.

Very best regards,

Rob Davis

Chairman & Chief Executive Officer

Health awareness

Why you shouldn’t postpone cancer screenings

Our company teamed up with the American Cancer Society to raise awareness on cancer screenings and help support access for everyone

August 15, 2024

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Fear is a powerful emotion, especially when it comes to cancer.

Fear of what a screening test might discover, fear of potential discomfort and fear of the unknown kept Terry Craft from getting a regular cancer screening.

He decided to see a doctor after an intense and painful episode of constipation, an appointment he says he should have had 10 years earlier. Craft was 47 years old when he was diagnosed with stage 3 colon cancer.

“My wife actually wanted me to have a colonoscopy when I was in my late 30s because I had a little bout and I said, ‘No, I’m not doing that,’” says Craft.

Terry Craft

“I didn’t get screened because I was afraid of it. I just didn’t want to know if there was something that might be serious or life-threatening. It was a fear factor for me.”

  • Terry Craft
    Colon cancer survivor

He says his doctors told him his tumor had potentially been growing ever since that experience in his 30s.

“Had I gone for a simple screening 10 years prior I might have, as I say, ‘nipped it in the bud’ and it might have just been a rogue polyp, who knows,” says Craft. “But because I didn’t, I had to go through a lot and it wasn’t just me — when cancer affects one member of a family, it affects everyone.”

“Due to pandemic-related delays in screening for breast, cervical, colorectal and lung cancers, many cancers could be going undiagnosed and untreated and may advance to later stages and be more difficult to treat,” says Laura Makaroff, senior vice president of prevention and early detection at American Cancer Society. “We foresee that those reductions in health care access and cancer screening will result in a short-term drop in cancer diagnoses and a later corresponding increase in late-stage diagnoses and potentially preventable deaths. “

Craft is in remission today, and he makes it a point to tell others just how important cancer screenings are, no matter what the results might be.

“It’s OK to understand what’s going on,” says Craft. “You want to know, don’t hide from it. If you hide from it, the outcome might not be what I experienced. It could be a deadly outcome.”

Early detection matters

Darleen Alston didn’t have health insurance when she was diagnosed with breast cancer in 2019. She says if it wasn’t for the free mammogram that she received through a cancer screening program, it “could have been months” before she knew she had cancer.

Darlene Alston

“I can say that it [screening] saves lives because it saved mine.”

  • Darleen Alston
    Breast cancer survivor

While many people face different kinds of barriers to getting the medical care they need, having access to preventative health screenings shouldn’t be one of them.

“I tell everybody, go get your mammogram. And if you can’t afford it, go to the screening. They’ll do it for free,” says Alston. “You’re not going to lose anything by going. You’re going to lose your life, maybe, if you don’t go.”

Preventative care is for everyone

There are cancer screening resources available to help people who are uninsured or underinsured find low-cost or free cancer screenings.

To help these efforts and improve cancer screening rates, Merck teamed up with the American Cancer Society (ACS) and their Get Screened campaign.

Our company, along with other sponsors, joined ACS in its goal to raise $30 million for a national initiative to help support access to recommended cancer screenings. The initiative includes collaborations with key stakeholders, including state and local health systems, to implement evidence-based screening interventions and public policy solutions that may benefit all.

“It’s important to ensure access for everyone to recommended cancer screenings to reduce screening disparities and unnecessary cancer deaths,” says Makaroff. “During the pandemic, we know that disparities in cancer screenings increased for people with greater social or economic barriers. Through our Get Screened campaign, the American Cancer Society is working to increase regular screening rates for everyone to help save more lives.”

Health awareness

HPV and related cancers: What you need to know

Human papillomavirus (HPV) is a leading cause of certain types of cervical cancer and other cancers in men and women

August 15, 2024

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What is human papillomavirus (HPV)?

Human papillomavirus (HPV) is the most common sexually transmitted infection (STI) in the U.S. There are many different types of HPV.

For most people, HPV clears on its own. But for the very few who do not clear the virus, it can cause certain cancers and other diseases in both men and women. Unfortunately, there’s no way to know who will or will not clear the virus.

What cancers and diseases can be caused by HPV?

icon of people connected in a circle

HPV can cause certain types of:

  • cervical cancers
  • anal cancers
  • vulvar cancers
  • vaginal cancers
  • head and neck cancers
  • genital warts

According to the U.S. Centers for Disease Control and Prevention (CDC), between 2016 and 2020, tens of thousands of people in the U.S. were diagnosed with certain HPV-related cancers each year.

The impact of HPV-related cancers

Between 2016 and 2020, CDC estimates:

icon
60-70%

of all oropharyngeal cancer (found in the back of the throat, including the base of the tongue and tonsils) may be caused by HPV

icon
~11,900

new HPV-related cervical cancer cases occur in the U.S. each year

“There are steps people can take to be proactive about their health. Men and women should speak with their health care providers to learn more about the link between HPV and certain cancers and diseases.”

— Mel Kohn, M.D., M.P.H., executive director of medical affairs, Merck

The World Health Organization’s movement towards cervical cancer elimination

According to the World Health Organization (WHO), cervical cancer is the fourth most frequent cancer in women globally. Important steps have been taken to achieve a world where fewer women are affected by cervical cancer, but more needs to be done.

In 2020, the World Health Assembly adopted the global strategy to accelerate the elimination of cervical cancer as a public health problem.

To help achieve this goal, the WHO provides guidance and tools to support countries in implementing strategies and addressing challenges associated with cervical cancer prevention.

Innovation

Our Q2 2024 sales and earnings report

July 30, 2024

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Merck’s (NYSE: MRK) Q2 2024 results demonstrate strong business momentum and further progress in our diverse pipeline. Our company announced worldwide sales of $16.1 billion, an increase of 7% from Q2 2023.

“Our business is demonstrating strong momentum as we exit the first half of the year,” said Rob Davis, chairman and chief executive officer. “Through excellent scientific, commercial and operational execution, we’re achieving significant milestones for our company and for patients. I am proud of our dedicated teams around the world that are working tirelessly to advance our deep pipeline as we continue delivering innovation that solves unmet medical needs.”​

Merck anticipates full-year 2024 worldwide sales to be between $63.4 billion and $64.4 billion. ​

Find more details on Q2 2024 results below.

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Our people

Our former CEO Dr. Roy Vagelos honored for role in helping China combat hepatitis B  

We’re proud of his recognition and our continued commitment to global health

July 16, 2024

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Roy Vagelos

It’s a moment that’s woven into our company’s history, and one that exemplifies our commitment to putting people before profits. 

In 1989, when hepatitis B was the largest public health challenge in China, our company shared a manufacturing process to help the Chinese government address this public health need. This cooperation, led by then-CEO Dr. Roy Vagelos, helped millions at a time when they needed it most.  

For his role in helping the people of China, Vagelos recently received the first-ever Elimination Champion Legacy Award from the Coalition for Global Hepatitis Elimination (CGHE), a program of The Task Force for Global Health. Vagelos was honored alongside Professor Zhao Kai, who helped lead China’s participation in the technology transfer.  

“Dr. Roy Vagelos and Professor Zhao Kai are fully deserving of the first Legacy Awards as Hepatitis Elimination Champions,” said Dr. John W. Ward, director of the CGHE. 

By 2009, China’s vaccination program made possible by this technology transfer prevented over 24 million infections and over 4 million future deaths, according to estimates cited by the Coalition for Global Hepatitis Elimination. Vagelos’ leadership exemplifies our company’s legacy of collaboration and the work we do every day to address some of the world’s most pressing public health challenges.