Innovation

Teaming up with Eisai to help fight cancer

How we're leveraging each other’s unique strengths to help advance cancer research

April 10, 2024

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Combining two ambitious cancer research teams to form a united front to help people with cancer

It’s sometimes said that the whole is greater than the sum of its parts. That’s why in 2018 we teamed up with Eisai, a global pharmaceutical company headquartered in Japan, to work together to advance cancer research.

“Combining Merck’s leadership in immuno-oncology with Eisai’s strengths in small molecules allows us to advance a combination approach that has the potential to help more people living with challenging cancers,” says Dr. Gregory Lubiniecki, vice president, global clinical development, Merck Research Laboratories.

Dr. Takashi Owa

"There's still an unmet need for many patients with cancer. These patients and their families are in need of more treatment options, and this remains at the forefront of our collaborative efforts."

Dr. Takashi Owa

Vice president, chief medicine creation and chief discovery officer, oncology business group, Eisai

Together, we’re striving to drive cancer science forward, and this shared vision has led to multiple clinical trials investigating the companies’ combination treatment option in various tumor types.

Through this comprehensive approach, we’ve been expanding the joint clinical program to help as many cancer patients as possible.

Why did you decide to go into oncology research?

“My decision was very personal,” says Owa. “At the age of six, my grandmother passed away from gastric cancer. I couldn’t fully process what had happened to her at that young age. It wasn’t until I entered junior high school that I began to understand the toll cancer had taken on her, which motivated me to learn about cancer and find my passion in cancer research.”

Lubiniecki’s experience was also very personal.

“Watching my mother recover from breast cancer while I was in high school exposed me to the challenges patients face when battling cancer. These experiences inspired me to ultimately pursue oncology,” explains Lubiniecki. “Oncology clinical research offers an opportunity to impact the practice of medicine greatly.”

Looking to the future

“I’m proud of what we’ve been able to accomplish together in our pursuit to investigate additional options for patients across a broad range of cancer types through our robust clinical development program,” says Lubiniecki.

Owa is optimistic about the progress the two teams have made together. “We’ve already seen encouraging anti-tumor activity in several difficult-to-treat cancers, which has led to multiple milestones to date,” he says. “As we continue to enhance our knowledge and scientific evidence through our ongoing clinical research efforts, together, we aim to give patients and their families hope.”

Lubiniecki believes that collaborations are important to continuing to advance cancer research and improve the outcomes of people with cancer.

Dr. Greg Lubiniecki smiling

“A collaborative approach is key to advancing science and making strides in drug discovery and development.”

Dr. Gregory Lubiniecki

Vice president, global clinical development, Merck Research Laboratories

“Working with others driven by the same patient-centric goals can yield innovations and is imperative to continued progress in improving patient care,” says Lubiniecki. “I’m thrilled to be a part of this collaboration as we continue to advance and expand the clinical trial program.”

Innovation

How Merck scientists are driving next-generation cancer research

Our scientists are accelerating research by looking to improve anti-tumor immune response, targeting specific cancer cells and helping inhibit cancer growth

March 29, 2024

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In recent decades, our improved understanding of cancer has illuminated that we cannot treat all cancers as one disease — scientists have classified hundreds of types and found a myriad of genetic drivers underlying them. This means, just as cancer isn’t one disease, there cannot be just one way to treat all cancers.

“We’ve witnessed dramatic progress in how we treat a wide range of cancers, and our work at Merck has been foundational in how we treat metastatic disease, or cancer that has spread.”

  • Dr. Jane Healy
    Vice president and head of oncology early development, Merck Research Laboratories

“This is just the tip of the iceberg. These advancements are helping to fuel the next generation of discoveries and drive progress in the way we care for people with all stages of cancer. We must push research forward that supports early discoveries and novel innovations to advance the future of cancer research,” Healy said.

Driving research toward treating certain cancers earlier

With the ultimate goal of providing patients with the greatest chance for survival, our researchers are building a broad clinical development program focused on treating certain cancers at earlier stages.

“Expanding our research efforts into earlier stages of disease remains a top priority,” said Healy. “We’re pursuing research where we have the greatest potential to make a significant impact in helping reduce the risk of recurrence and improving survival.”

A robust pipeline of diverse approaches to advanced and earlier stages of cancer

In addition to driving research in earlier stages of cancer, Healy and her colleagues are investigating multiple mechanisms and modalities that may have the potential to address cancer in innovative ways. Through our own research and external collaborations, we’ve developed a robust pipeline that encompasses diverse approaches to treating advanced and earlier stages of cancer across more than 20 novel mechanisms, including:

  • Boosting anti-tumor immune responses: Learnings from recent advancements in cancer care have informed a more focused approach to research. Now, we’re investigating foundational cancer treatments combined with negative immune regulators that play different roles in adjusting the immune response.

    We’re also exploring individualized neoantigen therapies, a growing area of research focused on sharpening the immune response against a person’s own tumor by developing a therapy unique to their tumor’s mutation.
  • Tissue-specific targeting of chemotherapy to increase cancer cell sensitivity to immune responses: While chemotherapy remains an important treatment option, our scientists are exploring how antibody-drug conjugates (ADCs), with novel chemotherapy-like payloads, can be used as a more targeted approach to deliver chemotherapy.

    Similarly, we’re pursuing research that enhances the ability of T cells to recognize and attack tumors.
  • Impacting pathways that can drive cancer growth: We’ve identified opportunities for the direct targeting of cancer cell vulnerabilities and transcription factors that were previously considered untreatable. By designing therapeutic candidates that inhibit or degrade proteins and genes implicated in cancer pathways, we’re evaluating new ways to help address rare and difficult-to-treat cancers that currently have limited treatment options.

"We're committed to investing in novel research where scientific opportunity and medical need converge. "

— Jane Healy

“These key areas of research are the cornerstones of our broad and diverse pipeline, with more than 2,250 ongoing clinical trials, which include more than 1,600 trials evaluating combination regimens. We remain dedicated to discovering new ways to fight this disease and optimizing existing approaches — all while continuing to lead in supporting the next generation of cancer research,” said Healy.

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Learn more about our oncology pipeline

Innovation

Our Q4 and full-year 2023 earnings report

February 1, 2024

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Merck’s (NYSE: MRK) Q4 and full-year 2023 results reflect sustained growth across oncology and vaccines. Our company announced Q4 worldwide sales of $14.6 billion, an increase of 6% from Q4 2022. Full-year 2023 worldwide sales were $60.1 billion, an increase of 1% from full-year 2022. ​

“2023 was another very strong year for Merck. I am extremely pleased by the progress we’ve made to develop and deliver transformative therapies and vaccines that will help save and improve lives around the world. We reached more than 500 million people with our medicines last year alone, over half of which were donations, including through our program to treat river blindness,” said Rob Davis, chairman and chief executive officer. “We also made investments of approximately $30 billion in research and development in our ongoing effort to discover, develop and collaborate to propel the next generation of impactful innovations. As we move forward, I’m confident that our strong momentum will continue, underpinned by the unwavering dedication of our talented global team.”​

Merck anticipates full-year 2024 worldwide sales to be between $62.7 billion and $64.2 billion.​

Take a look at the infographic below for more details on Q4 and full-year 2023 results.

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2023 q4 financial result
Innovation

The Wall Street Journal names Merck among top 10 best-managed companies 

We’re proud to be recognized for our strong performance and unwavering commitment to patients

January 11, 2024

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Our company has been recognized for our leadership and strong performance powering the work we do for patients and everyone who depends on us. We were named No. 10 on The Wall Street Journal’s list of the 250 best-managed publicly traded U.S. companies in 2023, advancing 78 places from the previous year.

Rob Davis

“This recognition reaffirms our strategic focus, innovation, hard work and collective, unwavering commitment to our purpose of saving and improving lives each and every day.”

— Rob Davis

Chairman and chief executive officer

“To make the list of The Wall Street Journal’s 250 best-managed companies is quite an honor,” Davis said, “and to be ranked in the top 10 is especially exciting and humbling.” 

This year, nearly 800 companies were scored. Placement on the list is determined by a company’s strength in five components:

  1. Customer satisfaction
  2. Employee engagement and development
  3. Innovation
  4. Social responsibility
  5. Financial strength

We placed first in customer satisfaction and were one of seven companies to score in the top 20% in each of the five components.

“Customer satisfaction is directly tied to the innovation we bring and the benefit we can deliver for patients,” Davis told The Wall Street Journal.

Top ranking for corporate citizenship 

In addition to our Wall Street Journal recognition, we’re deeply honored to be ranked No. 1 on Newsweek’s 2024 list of America’s Most Responsible Companies. This marks our first time in the lead spot, a distinction that affirms our steadfast commitment to operating responsibly and doing good for people and the planet.  

Innovation

Harnessing innovative technology in drug discovery

Merck scientists explain how new technologies can accelerate the drug discovery process as we use the power of leading-edge science to save and improve lives

November 16, 2023

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Our scientists are leveraging state-of-the-art capabilities to discover novel molecules that may lead to the medicines of tomorrow. 

Merck Research Laboratories (MRL) scientists evaluate hundreds to thousands to up to billions of compounds to find a starting point for a new drug candidate. It all starts with identifying a target — usually a protein — that’s intrinsically associated with a particular disease and can be pharmacologically modulated. That’s where innovative tools like structure-based design, high-throughput screening and high-throughput experimentation, coupled with robotics, artificial intelligence and machine learning can make a huge difference in progressing the work. And once a lead molecule is identified, cryogenic electron microscopy (cryo-EM) as an emerging structural method can be used to understand and improve how a molecule interacts with the protein target.

Utilizing the latest technologies and diligent work by teams of highly skilled and experienced scientists can potentially accelerate the discovery of new medicines for patients in need.

“We have an incredibly creative, smart and hardworking workforce. It’s an absolute pleasure to be part of that and to have access to the resources necessary for making scientific breakthroughs.”

— Adam Weinglass

Executive director in quantitative biosciences
Innovation

Breaking new ground in the UK

We’re accelerating our global efforts and capabilities with our new London Discovery Research Centre and U.K. headquarters

November 10, 2023

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Using the power of leading-edge science to help save and improve lives means tapping into scientific talent around the world. That’s why we’re proud to break ground on our new London Discovery Research Centre and U.K. headquarters.

The high-profile site — located opposite King’s Cross Station in the heart of London’s Knowledge Quarter, an impressive cluster of academic, scientific and technological institutions — will be an impactful addition to our growing network of research facilities.

“Our talented discovery scientists in London are an integral part of our global research network.”

  • Dean Li
    President of Merck Research Laboratories

“Patients around the world are waiting for innovations that will help confront the tremendous burden of disease they face, and the kind of world-class scientific exploration this facility will enable is how we accelerate those innovations,” Li added.

Slated to open in 2027, the 270,000-square-foot, 10-story facility will bring together all our U.K. colleagues to help drive medical advances against some of today’s greatest health challenges.  

“With the benefit of London’s thriving life sciences ecosystem and Knowledge Quarter right on our doorstep, I’m excited about the collaboration opportunities, building toward an exciting new chapter, and what this represents for employees and our partnership with the local community and beyond,” said Ben Lucas, managing director, U.K. and Ireland.

Innovation

Merck’s legacy of antimicrobial innovation and action

Delivering on our commitment to fight infectious diseases for more than a century

October 12, 2023

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For more than 100 years, Merck has contributed to the discovery and development of novel medicines and vaccines to fight infectious diseases. With the growing burden of antimicrobial resistance (AMR), we’ve focused on stopping the increasing threat of AMR

1930s

Merck Research Laboratories played a central role in the development of sulfas, the first synthetic antimicrobial.

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1940s

In collaboration with Rutgers University, we developed streptomycin, the first antibiotic effective against tuberculosis. We also helped to develop one of the first methods for mass production of penicillin.

scientist taking out trey of vial

1950s & 1960s

We developed multiple novel methods to prevent infectious diseases, including pediatric vaccines.

scientist working with equipment

1970s & 1980s

We received U.S. Food and Drug Administration (FDA) approval for two vaccines, as well as three antibiotics that treat a variety of bacterial infections.

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1990s & 2000s

Merck received U.S. FDA approval for two antifungals, as well as licenses for two vaccines.​

2002

With resistance to antibiotics developing faster through people, animals and the environment, we launched one of the world’s largest and longest-running antimicrobial resistance surveillance studies. Called the Study for Monitoring Antimicrobial Resistance Trends (SMART), the program enables researchers to monitor and identify trends in the development of AMR.

2010s

We launched an Antimicrobial Stewardship (AMS) Investigator Initiated Studies program, supporting investigator-based, peer-reviewed research supporting the implementation of AMS principles across the globe, with over 20% of studies occurring in low-and middle-income countries.

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2016

We created the Merck Exploratory Science Center in Cambridge, Massachusetts, focusing on the earliest stages of research into the underlying biology of human disease.

2016-2017

We supported the first United Nations high-level meeting on AMR and subsequent political declaration in 2016, which set policy action on AMR in motion.

As a next step, we joined the newly founded AMR Industry Alliance – a network of over 100 pharmaceutical industry partners working to provide sustainable solutions to help curb antimicrobial resistance.

AMR action fund logo

2020

Merck, along with a group of more than 20 leading biopharmaceutical companies, launched the AMR Action Fund to bring 2-4 new antibiotics to patients by the end of the decade.

2020s

Our staff have championed government actions to create supportive markets for antimicrobial innovation, including the PASTEUR Act in the U.S., inclusion of transferable exclusivity extensions in the EU pharmaceutical strategy, and other incentives around the world.

By collaborating with policymakers, Merck aims to improve appropriate antibiotic use globally.

cow drinking milk from bottle

Going forward

In recognition of our leadership in both human and animal health, Merck represents industry in the One Health Global Leaders Group on Antimicrobial Resistance, which advocates for a One Health approach to help ensure antibiotics remain an important tool in improving and maintaining human and animal health.

Innovation

How we’re collaborating to address antimicrobial resistance – and why we can’t do it alone

Shared commitments like the AMR Action Fund are vital to make progress against this public health threat

September 8, 2023

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Antibiotics have transformed health care and saved countless lives. But rising levels of antimicrobial resistance (AMR) can make current antibiotics less effective. There’s no simple solution to the complex problem of AMR, but we’re committed to investing our expertise and resources alongside our partners to get antibiotics to those who need them most. Lives are at risk, and the time to act is now.

Through this groundbreaking partnership of over 20 leading pharmaceutical companies, philanthropies and organizations, we aim to bridge the gap between the innovative early antibiotic pipeline and patients. True to our legacy of preventing and treating infectious diseases, we’re proud of our commitment to invest $100 million over 10 years in the AMR Action Fund. The fund’s collective goal is to bring two to four novel antibiotics to patients and physicians by 2030.

As of early 2023, the AMR Action Fund has invested in five small biotech companies advancing research for new medicines to fight some of the most dangerous bacteria as determined by the U.S. Centers for Disease Control and Prevention and the World Health Organization.

Here are five reasons collaborative efforts are key to addressing AMR:

01.


New antibiotics are urgently needed; however, there are relatively few in development.

The future of antibiotic innovation is at serious risk. Major scientific, regulatory and economic challenges discourage innovation in antibiotics, resulting in a decline in the number of companies conducting antimicrobial R&D. Recognizing there’s no one-size-fits-all solution to the problem, our company and others have suggested a series of policy reforms across several regions of the world. However, time is running out. We need collaboration from policymakers to help antibiotic innovation flourish for decades to come.

02.

Once new antibiotics are approved, they need to be used responsibly.

At Merck, we’re making significant investments to support antimicrobial stewardship (AMS), a broad term for the implementation of evidence-based policies to slow resistance to current antimicrobials. Our investments and partnerships help hospitals around the world develop and implement patient-centered AMS programs that are customized locally based on factors like epidemiology, clinical setting and resource availability to support the responsible prescribing and use of antimicrobials. We also provide significant grant funding to support a wide range of AMS initiatives and collaborations.

Some of our global contributions to AMS include:

  • Supporting the development of several AMS Centers of Excellence throughout the world.
  • Helping public health leaders effectively monitor and address emerging AMR infections, promote AMS and customize accepted AMS strategies to meet local needs.
  • Providing significant grant-funding for numerous investigator-initiated AMS research projects.

03.

Tracking resistance trends and using data to help doctors prescribe the right medicines remains critical.

Our company has been tracking global resistance trends for over 20 years. This data helps doctors prescribe the right medicines. One of the largest and longest-running AMR surveillance programs, our Study for Monitoring Antimicrobial Resistance Trends (SMART) program has collected nearly 500,000 Gram-Negative bacterial isolates from around 220 sites in more than 60 countries since 2002.

We’re also a partner of the AMR Register, a first-ever online platform that allows pharmaceutical companies to securely share data on infection-causing pathogens with researchers, national governments and multilateral organizations working to fight AMR.

04.

AMR extends beyond human health.

The challenge of AMR is multifaceted, and a One Health approach to creating policies is critical to attain optimal health for people, animals and the environment.

When it comes to animal health, vaccines can help minimize the need for antibiotics. Merck Animal Health is one of the largest manufacturers of animal health vaccines, supplying over 102 billion doses each year.

Protecting the environment through responsible manufacturing is another key component of the One Health approach. We work with our partners in the AMR Industry Alliance to inform science-based manufacturing standards to help ensure scrutiny of industry manufacturing supply chains.

05.

The time to act against AMR is now.

With collaboration across the scientific community and policymakers, AMR is preventable.

We all have a role to play as we prepare for the next health crisis. We must act now to put measures in place to ensure we have the antibiotics we need.

“AMR is not a future problem — it’s here now, threatening human, animal and environmental health as we know it. We must take swift, collaborative action to help reduce the risk of AMR before it’s too late,” said Jennifer Zachary, executive vice president and general counsel at Merck and member of the Global Leaders Group on AMR.

To learn more about the investments that the AMR Action Fund is making to help ensure patients and physicians have access to effective antimicrobials –- now and in the future –- please visit their website.

Innovation

Podcast: Why neuroscience is the ‘final frontier’

Listen as specialists from Merck discuss what they’re most excited about in researching potential treatments for neurologic disorders

July 11, 2023

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Our scientists are revolutionizing how we discover and develop treatments to address unmet medical needs in a number of areas, including neuroscience.

“It’s sort of like the final frontier,” said Joe Herring, scientific AVP, clinical research, in our new podcast. “You’re going off into space to try to figure out how to do very difficult things.”

For more, listen in as Herring sits down with Merck clinical research team senior principal scientists Yuki Mukai and Ari Merola as well as business development director Paige Lacatena to explore today’s breakthroughs and challenges in the field of neuroscience.

Listen to the podcast

Read the full transcript

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Innovation

Individualized neoantigen therapies: exploring one medicine for one patient

Scientists are researching new ways to help train the immune system to fight cancer

April 13, 2023

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Merck's Dr. Jane Healy

Over the past decade, immunotherapy has transformed our understanding of how the immune system can be used to help fight some types of cancer. However, for the last 50 years, scientists have been researching how we could potentially use vaccines to treat cancer — another investigational approach to harness the immune system to help recognize and destroy cancer cells — with little success.

Now we’re looking at a potential therapy that is building upon the learnings of immunotherapy trials from the past and incorporating that into an individualized cancer approach that’s specific to a patient’s own tumor. Researchers are currently exploring the potential of individualized neoantigen therapies to help fight cancer.

Cancer research is becoming more personalized

Cancer is a result of the body’s own cells undergoing mutations which create abnormal proteins in cancer cells, known as neoantigens, that are not usually seen in normal cells. These mutations are unique to each person’s tumor, so that’s one of the reasons why patients who have been diagnosed with the same type of cancer and who have received the same type of treatment may have different responses.

As the treatment of cancer continues to evolve and advance, researchers are focusing on more individualized approaches. This includes a new area of research into individualized neoantigen therapies that use information from a person’s tumor biopsy sample to help develop a therapy unique to their tumor’s mutations.

Merck's Dr. Jane Healy

“This area of research has really captured our imagination of what’s possible in the development of cancer therapeutics.”

  • Dr. Jane Healy
    Vice president and head of oncology early development at Merck Research Laboratories

In collaboration with Moderna, we’re studying this area of research in an effort to advance more individualized approaches to help improve outcomes for people living with cancer.

Learn more about individualized neoantigen therapies

infographic of what is an individual neoantigen therapy