Our Pipeline at a glance

Mechanism of Action: MK-7262 is an oral lipoprotein(a) inhibitor.

MK-7262 is being developed under an agreement with Jiangsu Hengrui Pharmaceuticals Co., Ltd.

Mechanism of Action: MK-3120 is an investigational Nectin-4 antibody with topo I inhibitor payload.

Mechanism of Action: Gocatamig is a tri-specific T-cell activating construct (TriTAC) targeting DLL3.

MK-6070 was acquired as part of the acquisition of Harpoon Therapeutics.

Mechanism of Action: Ensifentrine (+) glycopyrrolate is a combination of a selective dual inhibitor of phosphodiesterase 3 and 4 (PDE3 and PDE4) and a long-acting muscarinic antagonist.

Mechanism of Action: Doravirine is a pyridinone non-nucleoside reverse transcriptase translocation inhibitor of HIV-1. Islatravir is an investigational nucleoside reverse transcriptase translocation inhibitor of HIV-1.

MK-8591A is on FDA partial clinical hold for higher doses of islatravir than those used in current clinical trials.

Islatravir is being developed under an agreement with the Yamasa Corporation.

Mechanism of Action: Clesrovimab is a respiratory syncytial virus (RSV) fusion (F) glycoprotein neutralizing monoclonal antibody.

Mechanism of Action: MK-2214 is an investigational, high-affinity antibody specific for tau.

Mechanism of Action: MK-8748 is a TIE2 receptor agonist and VEGF antagonist bi-functional Fc-fusion protein.

MK-8748 was acquired as part of the acquisition of Eyebiotech Limited (EyeBio).

Mechanism of Action: MK-1167 is an alpha-7 nicotinic acetylcholine receptor positive allosteric modulator.

MK-1167 is being developed under a collaboration with Neuphoria.

Mechanism of Action: MK-3000 is an investigational tri-specific antibody that acts as an agonist of the Wingless-related integration site (Wnt) signaling pathway.

This program is in Phase 2/3 studies.

MK-3000 was acquired as part of the acquisition of Eyebiotech Limited (EyeBio).

Mechanism of Action: MK-1084 is an investigational, oral selective KRAS G12C inhibitor.

MK-1084 is being developed in combination with KEYTRUDA.

MK-1084 is being developed through a collaboration with Taiho Pharmaceutical Co. Ltd and Astex Pharmaceuticals (UK), a wholly owned subsidiary of Otsuka Pharmaceutical Co., Ltd.

Mechanism of Action: Raludotatug deruxtecan is an investigational antibody-drug conjugate that consists of a humanized anti-CDH6 IgG1 monoclonal antibody linked to a topoisomerase I inhibitor payload.

Raludotatug deruxtecan is being developed in collaboration with Daiichi Sankyo.

Mechanism of Action: MK-8527 is an investigational nucleoside reverse transcriptase translocation inhibitor (NRTTI) of HIV-1.

Mechanism of Action: Patritumab deruxtecan is an investigational antibody-drug conjugate that consists of a fully human anti-HER3 IgG1 monoclonal antibody linked to a topoisomerase I inhibitor payload.

Patritumab deruxtecan is being developed as a monotherapy and/or in combination with KEYTRUDA.

Patritumab deruxtecan is being developed in collaboration with Daiichi Sankyo.

Mechanism of Action: Ifinatamab deruxtecan is an investigational antibody-drug conjugate that consists of a humanized anti-B7-H3 IgG1 monoclonal antibody linked to a topoisomerase I inhibitor payload.

Ifinatamab deruxtecan is being developed in collaboration with Daiichi Sankyo.

Mechanism of Action:  Tulisokibart is an investigational humanized monoclonal antibody directed to tumor necrosis factor (TNF)-like ligand 1A (TL1A).

 Tulisokibart was acquired as part of the acquisition of Prometheus Biosciences, Inc.

Mechanism of Action: Bomedemstat is an investigational lysine-specific demethylase-1 (LSD1) inhibitor.

Bomedemstat was acquired as part of the acquisition of Imago BioSciences, Inc.

Mechanism of Action: Pembrolizumab is a monoclonal antibody that binds to the PD-1 receptor and blocks its interaction with PD-L1 and PD-L2, releasing PD-1 pathway-mediated inhibition of the immune response.

*MK-3475A to be marketed under the trade name KEYTRUDA SC in the EU.

Description: V181 is an investigational quadrivalent dengue vaccine.

Mechanism of Action: Opevesostat is an investigational oral inhibitor of cytochrome P450 11A1.

Opevesostat is being developed in collaboration with Orion.

Mechanism of Action: Sacituzumab tirumotecan is an investigational antibody-drug conjugate that consists of an antibody-targeting trophoblast cell-surface antigen 2 (TROP2) linked to a belotecan-derived payload.

Sacituzumab tirumotecan is being developed as monotherapy and/or in combination with KEYTRUDA.

Sacituzumab tirumotecan is being developed in collaboration with Sichuan Kelun-Biotech.

Mechanism of Action: Islatravir is an investigational nucleoside reverse transcriptase translocation inhibitor of HIV-1. Lenacapavir is an investigational, long-acting HIV-1 capsid inhibitor.

MK-8591D is on FDA partial clinical hold for higher doses of islatravir than those used in current clinical trials.

Islatravir is being developed under an agreement with the Yamasa Corporation. The combination of islatravir and lenacapavir is being developed in a collaboration with Gilead Sciences, Inc.

Mechanism of Action: enlicitide decanoate is an investigational inhibitor of Proprotein convertase subtilisin/kexin type 9 (PCSK9).

Mechanism of Action: Sotatercept is an activin signaling inhibitor that binds to activin A and other TGF-β superfamily ligands.

Sotatercept was acquired as part of the acquisition of Acceleron.

Mechanism of Action: Belzutifan is an inhibitor of hypoxia-inducible factor 2 alpha (HIF-2α). Belzutifan binds to HIF-2α, and in conditions of hypoxia or impairment of VHL protein function, belzutifan inhibits the HIF-2α-HIF-1β interaction, leading to reduced transcription and expression of HIF-2α target genes.

WELIREG is being developed as a monotherapy and/or in combination with KEYTRUDA.

WELIREG was acquired as part of the acquisition of Peloton Therapeutics, Inc.

Mechanism of Action: Zilovertamab vedotin is an investigational antibody-drug conjugate that consists of a ROR1-targeting antibody linked to monomethyl auristatin E (MMAE)-containing payload.

Zilovertamab vedotin was acquired as part of the acquisition of VelosBio.

Mechanism of Action: Pembrolizumab is a monoclonal antibody that binds to the PD-1 receptor and blocks its interaction with PD-L1 and PD-L2, releasing PD-1 pathway-mediated inhibition of the immune response.

**Select KEYTRUDA clinical trials are shown.

Mechanism of Action: Efinopegdutide is an investigational dual GLP-1/glucagon receptor agonist.

Efinopegdutide is being developed under an agreement with Hanmi Pharmaceutical.

Mechanism of Action: Quavonlimab is an investigational monoclonal antibody that binds to CTLA-4 and inhibits interaction with its ligands. Pembrolizumab is a monoclonal antibody that binds to the PD-1 receptor and blocks its interaction with PD-L1 and PD-L2, releasing PD-1 pathway-mediated inhibition of the immune response.

Quavonlimab is being developed under an agreement with Akeso, Inc.

Mechanism of Action: MK-5475 is an investigational stimulator of soluble Guanylate Cyclase (sGC).

Mechanism of Action: Olaparib is an inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, including PARP1, PARP2, and PARP3.

LYNPARZA is being developed as a monotherapy and/or in combination with KEYTRUDA.

LYNPARZA is being developed in collaboration with AstraZeneca.

Mechanism of Action: Islatravir is an investigational nucleoside reverse transcriptase translocation inhibitor of HIV-1. Ulonivirine is an investigational non-nucleoside reverse transcriptase translocation inhibitor of HIV-1.

Islatravir is being developed under an agreement with the Yamasa Corporation.

Mechanism of Action:  V940 is an investigational mRNA-based individualized neoantigen therapy targeting tumor associated antigens expressed by a patient’s cancer cells.

V940  is being developed in combination with KEYTRUDA.

V940 is being developed in collaboration with Moderna.

Mechanism of Action: Molnupiravir is an investigational antiviral ribonucleoside prodrug of N-hydroxycytidine (NHC). NHC triphosphate is incorporated into viral RNA by viral RNA polymerase and results in an accumulation of errors in the viral genome leading to inhibition of replication.

LAGEVRIO is being developed under an agreement with Ridgeback Biotherapeutics LP.

LAGEVRIO is available in the U.S. under Emergency Use Authorization.

Mechanism of Action: Nemtabrutinib is an investigational reversible, non-covalent Bruton’s tyrosine kinase (BTK) inhibitor that is being studied for the suppression of oncogenic B-cell receptor signaling with activity against wild-type BTK and BTK pathway mutants.

Nemtabrutinib was acquired as part of the acquisition of ArQule, Inc.