Health awareness

Is your child up to date on their vaccines? Make a plan today

Keeping kids’ vaccinations current can help protect them against vaccine-preventable diseases

August 18, 2025

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smiling child with band aid on her arm

One of the many ways parents can help protect their kids from certain infectious diseases is by keeping them up to date on their recommended vaccines.

“Vaccines are powerful tools that can help protect against certain diseases. Making sure your kids are up to date on their vaccines is one way you can help protect them,” said Andrew “Drew” Otoo, PharmD, president of global vaccines from 2022-2025 and current regional president, Merck. “Speak with your child’s health care provider and ask about vaccines that may be recommended.”

In addition to scheduling vaccinations, child well-visits are essential for discussing concerns about children’s health and tracking growth and developmental milestones.

Dr. Andrew Otoo
Dr. Andrew “Drew” Otoo

“For all of us, let’s get creative. We’ve seen what our communities can do when it comes to new and effective ways to reach populations for vaccination.”

Even small actions can have an impact. Parents and community members can make a point to talk about routine and recommended vaccinations. Health care providers can use electronic health records and immunization registries to remind parents to schedule well-child visits for children who may be overdue for a check-up.

It’s critical to improve and maintain high vaccination rates

In 2023:

~21M

~21 million children around the world were either unvaccinated or undervaccinated in 2023. 14.5 million children did not receive any vaccines, almost 2 million more than in 2019, according to UNICEF.

40%

40% of adults in the U.S. feel it is “extremely important” for parents to have their children vaccinated, down from 58% in 2019 and 64% in 2001. (Gallup, July 1-21, 2024).

Persisting challenges around vaccination equity and confidence can lead to drops in vaccination coverage rates, putting children and individuals of all ages at risk of potentially serious, yet vaccine-preventable, diseases.

“Our purpose is clear: How can we continue to increase vaccination rates for all recommended vaccines for all populations, including underserved communities, to help protect public health? There is an urgency to this work,” said Otoo.

Health literacy is also key in these efforts. When you understand health information, you can make make informed health decisions.

“We’re surrounded by so much information coming at us from so many directions, and it can be hard to make sense of where to go for guidance or answers,” said Otoo. “It’s so important to make sure that we’re providing information that parents can understand to help them make informed decisions about vaccination for their families, as well as overall health care.”

For more than 100 years, Merck has been a pioneer in the fight against vaccine-preventable diseases. But the burden is still too high, and new threats to global health will emerge. That’s why we are continuing to invest in groundbreaking research and breakthrough technologies to help protect against a variety of potentially serious infectious diseases. We’re also collaborating globally, nationally and locally to build trust, enable access and improve vaccination rates.

We remain focused on helping to protect people around the world and across all stages of life.

Sustainability

Merck publishes Purpose for Progress Impact Report 2024/2025

August 18, 2025

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image of half of a petri dish and half of an earth merged to make a full circle. Text on top says

Our company’s purpose is to use the power of leading-edge science to save and improve lives around the world. This purpose serves as our compass and guides us every day. Our Purpose for Progress: Merck 2024/2025 Impact Report provides a comprehensive view of how we’re pursuing innovative science for the health of people and animals and ensuring our efforts drive significant and sustainable value.

“Our long-standing commitment and focus on advancing access to health, operating responsibly and implementing strategies that protect the health of people, animals and the planet is unwavering,” said Rob Davis, chairman and CEO. “As we continue to navigate the rapid pace of change happening all around us, I am proud of the progress we’ve made thus far, and I remain optimistic about our future.”

A few highlights from this year’s report*

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>247M

People enabled access to our innovative medicines and vaccines through access solutions.

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>66M

People reached with our social investments in low- and middle-income countries and in underserved populations in high-income countries. We've surpassed the goal of reaching 50 million by 2025.

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92%

Countries reached globally with our products, surpassing our goal for the fourth year in a row.

*All numbers as of 2024 (report page 15)

Our employees worldwide played a pivotal role in delivering novel solutions that addressed some of the world’s most serious and complex global health challenges. We’re proud that in 2024, our medicines and vaccines reached more than 450 million people around the world.

Our sustainability strategy has four main areas of focus

  • Access to health: In collaboration with global health stakeholders, our social investments aim to advance access to quality health systems, and we seek to ensure that our products are accessible and affordable worldwide.
  • Employees: We recognize that our ability to excel depends on the integrity, knowledge, imagination, skill, diversity of thought, perspectives and experiences, and well-being of our employees.
  • Environmental sustainability: We strive to operate our business sustainably, considering the impact on both the health of our planet and its inhabitants, while also providing opportunities for product innovation and reduction in costs and risks. We have a long history of environmental stewardship and compliance, and we continuously evolve our strategy and efforts in the face of a changing climate.
  • Ethics and values: Our ethics and values are at the center of everything we do. Through our unwavering commitment to transparency, we are committed to earning the trust and confidence of our stakeholders.

Learn more about our progress in these areas and read this year’s report.

Sustainability

We’re ‘seeing green’ and building a more sustainable business

Our award-winning ‘See Green, Be Green’ sustainability initiative exemplifies our company's and employees' commitment to operating responsibly

August 4, 2025

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Across our locations in Ireland, we’re taking the Emerald Isle ethos to heart with a call to “See Green, Be Green.”

See Green, Be Green is an employee-led initiative that aims to reduce our company’s environmental impact by embedding a sustainability mindset at every level of our operations. The program started in Ireland and has taken root across the organization, inspiring innovation, enhancing efficiency and driving progress toward our company’s climate goals.

“We decided to collectively develop, implement and maintain this program, not just because it’s the right thing to do, but because of our shared belief that sustainability-focused business is smart business. What we do — and how we do it — truly matters.”

  • Mark O’Connor
    Associate director of engineering in our energy and environmental sustainability center of excellence

Built around four focus areas — carbon transition, waste and water management, biodiversity and culture — See Green, Be Green is a framework that guides the sites’ sustainability efforts, from installing EV chargers and solar panels to planting pollinator gardens and native trees.

Colleagues from six of our Ireland locations — Ballydine, Brinny, Carlow, Biotech Dublin, Dunboyne, and Red Oak North — form a core team that identifies shared priorities and guides projects. The country leadership team, composed of plant managers, actively sponsors this initiative and provides strategic oversight. Cross-functional teams facilitate knowledge sharing among the sites to foster innovation and drive progress countrywide.

group of 9 people standing in front of office and smiling
Members of the See Green, Be Green core team in Carlow

“As individuals, you can definitely make a difference,” said James Maher, engineering specialist and See Green, Be Green lead in Carlow. “But when you come together as a group, the change can be massive.” 

Since the program’s launch, the sites have made significant strides in reducing greenhouse gas emissions, waste and water usage, earning numerous accolades along the way, including the top honor from the Irish business community’s Green Awards, which recognizes companies excelling in environmental innovation and leadership.

Our sustainability efforts in action

Carbon transition 

Reducing carbon emissions is critical to our company’s goal of achieving net zero by 2045. All six of our Ireland locations involved in the See Green, Be Green program have been certified in ISO 50001, an internationally recognized standard for managing energy, and in 2024 sourced 56% renewable energy through virtual power purchase agreements, making progress toward our company’s target to source 100% of our purchased electricity from renewable sources by 2025.

Other initiatives include installing solar panels, using electric company vehicles and transitioning from gas to electric boilers.

  

A 15-acre, 7.3-MW solar farm in Ballydine can generate the equivalent of powering more than 5,000 households with electricity; meeting pods in Dunboyne are outfitted with 160W 12V solar panels that supply power to the internal LED lights and USB charging points.

Waste and water management 

The Ireland sites send zero waste to landfill — key to our company-wide goal for at least 50% of sites to do so by 2025 — and are now working on improving other means of disposal, such as recycling rather than incinerating when possible, and donating items to organizations in need.

Other efforts include installing water fountains to replace single-use water bottles, harvesting rainwater and providing reusable coffee cups in company cafes.

Carlow
Office furniture from our Carlow site gets a new life at a community center; a new and improved waste segregation system was unveiled in Brinny during Sustainability Week 2024.

Biodiversity

All six locations involved in the See Green, Be Green program have been accredited with All-Ireland Pollinator Plan Business certifications. Initiatives include planting pollinator-friendly and native species of plants, trees and bulbs, installing bug hotels and adopting “No-Mow May” to aid clover growth.

A bug hotel at Biotech Dublin and wildflower planters at Red Oak North help attract pollinators.

Culture 

Arguably the most important part of See Green, Be Green is creating a culture in which everyone is empowered to take action. From educational campaigns and outreach events to grow-your-own food and energy-reduction challenges, employees are encouraged to embrace sustainability at work, at home and in their communities.

“We want everyone to get involved so that we can make informed decisions about our habits and how it impacts our environment,” said O’Connor.

tree planting and beach cleanup
Carlow colleagues plant native trees as part of a joint reforestation initiative in Ireland and Africa; Red Oak North colleagues help clean up Sandymount Strand in Dublin.

While the sites continue to challenge themselves to do more and do better, the initiative’s impact is already palpable.  

“It’s the mindset changes, it’s the momentum, it’s getting things done,” said Maher. “It’s the fact that our company really cares and that we’re taking real action.”  

woman and child smiling in a garden

Environmental sustainability

Beyond Ireland, the color green is a call to action that resonates deeply with our shared values. Together, we’re sowing the seeds for a brighter, healthier future for our communities and our planet.

Innovation

Our Q2 2025 financial results

July 29, 2025

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Merck’s (NYSE: MRK) Q2 2025 sales performance reflects strength across oncology and animal health, as well as increasing contributions from new launches. Our company announced Q2 worldwide sales of $15.8 billion.​

​”Earlier this month, we were pleased to announce our pending acquisition of Verona Pharma, which augments our portfolio and pipeline and is another example of acting decisively when science and value align,” said Rob Davis, chairman and CEO. “Today, we announced a multiyear optimization initiative that will redirect investment and resources from more mature areas of our business to our burgeoning array of new growth drivers, further enable the transformation of our portfolio, and drive our next chapter of productive, innovation-driven growth. With these actions, I am confident that we are well positioned to generate near- and long-term value for our shareholders and, most importantly, deliver for our patients.”​

​Merck anticipates full-year 2025 worldwide sales to be between $64.3 billion and $65.3 billion.​

​Take a look at the infographic below for more details on Q2 2025 results.

2025 Q2 Financial result

Download infographic

Innovation

Exploring KRAS: A precision approach in oncology

Merck scientists research oncogene mutations driving cancer growth

July 18, 2025

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3D depiction of KRAS protein complex
3D depiction of KRAS protein complex

How oncogenes like KRAS drive cancer growth

Armed with an ever-deepening understanding of cancer biology and advanced precision medicine tools, scientists have traced the molecular basis of cancer cell formation and tumor growth to alterations in key genes, known as oncogenes. Oncogenes play a crucial role in driving cancer growth by disrupting normal cellular processes that control cell growth and division.

When oncogenes are mutated, they cause cells to grow and divide uncontrollably, leading to tumor formation and cancer development. Understanding how oncogenes drive cancer development provides a potential means to explore new research approaches aimed at the specific genetic drivers of a patient’s cancer compared with a one-size-fits-all approach.

KRAS is one of the most frequently mutated oncogenes found in cancer. In healthy cells, KRAS serves as an on-off switch that regulates cell growth. However, when the gene is mutated, KRAS can become stuck in the “on” position, causing uncontrolled cancer cell growth and proliferation. Several different mutations of KRAS have been identified, and commonly found types include G12C, G12V and G12D.

The KRAS G12C mutation occurs in approximately 14% of non-small cell lung cancer (NSCLC) and 3-5% of colorectal cancers.

Dr. Jane Healy

“We now know there’s no one-size-fits-all approach to treating cancer. By focusing on key oncogenes like KRAS, we’re exploring how to harness precision approaches to potentially impact tumor growth at its source.”

  • Dr. Jane Healy
    Vice president and head of oncology early development, Merck Research Laboratories

Advances in targeting KRAS

Despite decades of research, the smooth, spherical structure of the KRAS protein hindered efforts to impact its activity on a molecular level. That’s because chemists often look for places to engage with the protein on its surface, like crevices or cracks.

After 40 years of research and informed by a greater understanding of the detailed structure of the KRAS protein, scientists have discovered ways to engage with a pocket that appears on KRAS when the protein is maintained in an inactive state.

Dr. Marjorie Green

“As we advance our KRAS research efforts, we’re hopeful that we may uncover new ways to impact the underlying processes that fuel cancer growth.”

  • Dr. Marjorie Green
    Senior vice president and head of oncology, global clinical development, Merck Research Laboratories

Today, our scientists are building on these findings to advance potential targeted approaches in oncology research. Our precision oncology research efforts are a key tenet in our robust oncology pipeline.

Our people

Meet two scientists at the forefront of our HIV research

Two esteemed scientists share their motivations and hopes for the future of HIV research

July 1, 2025

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Merck HIV researchers

The field of HIV research has changed drastically in the past 40 years. In that time, we’ve evolved from helping people with HIV struggle to survive to seeing them fully thrive. Now we’re chasing a cure for HIV.

We spoke with two of our own researchers who are leading the charge, Bonnie Howell, Ph.D., and Rebeca Plank, M.D., about what drives them, what’s changed and what’s next in the HIV research landscape.

What drew you to HIV research?

Plank: I think my interest was first sparked at home by my parents, who actually met doing public health work in Chile. But it’s funny, despite that background, I wasn’t pre-med in college. I was an anthropology major. But during my senior thesis, I worked on a project around HIV prevention messaging. That stuck with me.

audio file from Rebeca Plank

Howell: I can relate to that. I started working in HIV research after years of working in oncology and quickly recognized the unmet medical need. I realized that a lot of what I learned about cancer research could be applied to HIV as well.

I became passionate about HIV research because I saw it as an opportunity to change the storyline and apply my oncology experience to this different field.

In your mind, what’s been the biggest shift in HIV care?

Plank: I think the vast shift can be summed up by what I saw in med school. I was studying in San Francisco between 1996–2001, and I watched an inpatient hospital ward go from a place that housed critically ill people living with HIV to a general medicine ward full of people rightfully expecting to feel better and go back home.

And that’s all due to the fast and impactful medical innovations — such as antiretrovirals to treat HIV — that helped save so many lives.

In a field that’s been historically male dominated, how does it feel to be a female in science and HIV research?

Howell: My experience is definitely unique because I’ve been at Merck for my entire career — and I’ve been constantly surrounded by powerful and brilliant women. It’s been a privilege to be a part of a company that has empowered me to roll up my sleeves and contribute day in and day out to this important mission.

And I’m grateful for the chance to continue to add to the legacy Merck has established for itself in HIV — helping to change the way HIV has been treated since the start of the epidemic.

Plank: That said, there are still challenges facing women in HIV research. As a med student and also as a resident, it struck me that, looking around the hospital, there were relatively few women who were further along in their careers. It can be so important to see people succeeding who look like you, as role models and mentors — they show you what’s possible.

Howell: I completely agree. I also count myself lucky that I was mentored by female leaders who charted the course. Now I pay that forward and mentor the next generation of female researchers — especially those pursuing HIV.

Why do you think gender diversity is critical in HIV research?

Howell: Globally, women bear a huge brunt of this epidemic. A 2024 report showed that 53% of all people living with HIV in 2023 globally were women and girls.

It’s important to make sure that the female perspective is represented within the HIV research community, so women with HIV can have advocates who share and understand their unique female experiences.

Plank: Prior to joining Merck, during my time doing field work in Kenya and Botswana, I learned a lot about the nuances and unique hardships of the female HIV experience. Globally, advocating for herself may not always be a woman’s first priority. Not to mention that the stigma of HIV is still too prevalent around the world, which may make it harder to seek care.

Bonnie Howell

What advancement in HIV research do you hope to see during your lifetimes?

Howell: A cure. Whether that’s eradicating HIV from peoples’ bodies or remission, where the virus still exists in the body but is controlled without lifelong treatment.

Plank: And then getting this cure — as well as other treatments and better methods for HIV prevention — to people in need, in the manner they need it. Access remains a huge issue, and part of that is the mode of treatment such as frequency of pills or injections. We hear consistently that having discreet treatment and prevention options would be critical.

What gives you the most hope?

Plank: So much can evolve in a single generation. These young women we’re working to help, someday they’ll be grandmothers. By empowering them with knowledge and by continuing our work in HIV, we hope to protect future generations.

Howell: The HIV community is so passionate and engaged, and we’re designing studies and treatments with those affected in mind. I’m excited to see what the future brings.

Health awareness

Navigating RSV disease: one family’s journey

As the leading cause of hospitalization for infants in the U.S., respiratory syncytial virus (RSV) can progress to severe illness for some babies

June 11, 2025

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Mom holding Charlotte

Caring for a child with respiratory syncytial virus (RSV) can be challenging. New parents Amanda and Jeremy thought they were as prepared as possible for any illness for their daughter Charlotte.

women wearing a mask comforting a child in hospital bed

Charlotte’s first night in the pediatric ICU.

They had an established pediatrician, supportive family and friends and a variety of resources and supplies on hand to help manage symptoms. But they weren’t prepared for Charlotte to progress from having what they initially thought was a cold, with a cough and runny nose, to being admitted to the pediatric intensive care unit for RSV at only 7 months old.

RSV is a contagious, widespread seasonal infection and the leading cause of hospitalization for infants under a year old in the U.S. Infants are among the populations most at risk of contracting the severe virus during their first RSV season, which typically starts in the fall and peaks in the winter in most regions of the U.S.

Charlotte’s experience with RSV

“Charlotte was a happy, chill baby. When she wasn’t happy, it was usually a sign that she was about to get sick,” said Amanda, who as a first-time parent hadn’t thought much about RSV up until that point.

On the day Charlotte was cleared to go home.

As Charlotte’s symptoms worsened, their doctor told Amanda and Jeremy what to look out for, mainly retracting or pulling in between and under the ribs, which was a sign of her struggling to breathe.

Amanda and Jeremy were surprised when Charlotte was admitted for difficulty breathing due to RSV and stayed in the pediatric ICU for a week.

Fortunately, she recovered and Amanda and Jeremy were so appreciative of her medical care. Today, Charlotte is a healthy and happy 3-year-old who loves spending time with her parents and younger brother.

Amanda understands that her family’s experience is unfortunately not unique.

"I urge all parents to understand the signs and symptoms of RSV so you can be prepared."

— Amanda

The impact of RSV on infants

RSV is a common seasonal respiratory infection that can be spread through virus droplets when an infected person coughs or sneezes, or through direct contact with the virus, like kissing the face of a child with RSV.

It’s the most common cause of hospitalization in infants under one year old in the U.S.

Common symptoms include a runny nose, fever, coughing and wheezing. While RSV doesn’t usually cause severe illness, healthy and at-risk infants can develop more severe cases that may lead to illnesses such as bronchiolitis (inflammation in the small airways of the lungs) or pneumonia (infection of the lungs) and may require hospitalization.

doctor icon

It’s important for caregivers to speak with a health care provider to learn more about RSV and its symptoms.

Our people

A lifelong commitment to addressing dengue fever

How our colleague’s personal experience fueled his desire to help others

June 10, 2025

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A mosquito sitting on a baby's hand

With roughly half of the world’s population at risk of contracting dengue fever, Dr. Bin Pangilinan and his colleagues are dedicated to helping address this global health challenge.

Growing up in the Philippines, Pangilinan experienced firsthand the serious impact of dengue, one of the fastest-growing mosquito-borne viral diseases. He saw classmates become ill from the disease and, even though it was not contagious, unfortunately contracted it himself from infected mosquitos multiple times throughout his childhood. The care he received helped shape the course of his life in profound ways.

Pangilinan around 7 years old

His first encounter with dengue at age 7 landed him in the hospital, an experience marked by high fevers and severe body aches. “You would hear about outbreaks in the news, but being at the center of one was entirely different,” he said.

At age 10, a more severe episode required a two-week stay in the hospital — alarming both him and his parents. Finally, at age 15, Pangilinan was diagnosed with dengue once again, a third hospitalization disrupting his college admission tests and highlighting the disease’s unpredictability.

Joining the fight against dengue

His experience with dengue as a child ignited Pangilinan’s passion for medicine, driving him to pursue a career helping others. After completing his medical training, he faced dengue from the other side as a medical intern. “It was one of the most challenging moments in my medical career,” he said. “Treating patients impacted by dengue was a pivotal moment that further fueled my desire to help address this disease.”

Pangilinan during his medical training

Pangilinan’s career journey eventually led him to Merck in 2013, where he’s worked with various groups including advocacy, medical affairs, access and policy to help address infectious diseases. His personal journey inspires his professional work with a unique empathy and understanding, particularly in his current role, where he is part of a team supporting efforts to alleviate the burden of dengue and infectious diseases.

“The commitment of my colleagues and the dedication of the global public health community to fight dengue are incredibly inspiring,” Pangilinan said.

“That passion energizes me every day and drives me to confront this disease and make a difference for those at risk around the world, especially for my hometown in the Philippines, where my story with dengue began.”

Pangilinan and his colleagues remain committed to leveraging science, innovation and collaboration to help address the impact of infectious diseases like dengue on communities around the world.

Dengue facts and figures

Health awareness

Infectious disease detection and prevention

Learn more about how to detect and help prevent many infectious diseases

June 2, 2025

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Adult holding a child while she hands on monkey bar

Infectious diseases are illnesses caused by pathogenic microorganisms such as bacteria, viruses, fungi and parasites that can spread directly or indirectly from one person to another. These diseases can range from mild to severe and can affect various bodily systems, potentially leading to significant health complications and, in some cases, death.

Vaccination is one way we can help protect against certain infectious diseases. However, in recent years, vaccination rates have been declining, which has contributed to outbreaks of some infectious diseases. For example, measles was declared eliminated; yet in 2019, there was a large measles outbreak in the U.S. with 1,274 cases reported across 31 states, which was the greatest number of cases reported in the country since 1992. And as recently as 2025, outbreaks continue to appear in parts of the U.S.

Outbreaks like these are a worrying sign of a heightened risk for the spread of vaccine-preventable diseases.

Information about certain infectious diseases 


Hepatitis A    |    Hepatitis B     |     Measles     |     Mumps   I    Rotavirus   I    I Rubella

Hepatitis A

Hepatitis A is a disease of the liver caused by the hepatitis A virus, which spreads when someone ingests the virus, usually through person-to-person contact or by consuming contaminated food or drink. Those infected may feel sick for a few weeks or several months.

Signs and symptoms of hepatitis A

  • Dark urine or clay-colored stools
  • Feeling tired
  • Diarrhea
  • Fever
  • Joint pain
  • Loss of appetite
  • Nausea
  • Yellow skin or eyes (jaundice)

Potential risks and complications

In rare cases, hepatitis A can cause liver failure and death.

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Hepatitis B

Hepatitis B is a disease of the liver that’s transmitted when blood, semen or another body fluid from a person infected with the hepatitis B virus enters the body of someone who is uninfected (e.g., during sexual contact or childbirth). The disease can range from a mild, acute illness lasting a few weeks to a serious long-term, chronic infection.

Illustration of young girl

Signs and symptoms of hepatitis B

  • Dark urine or clay-colored stools
  • Feeling tired
  • Fever
  • Joint pain
  • Nausea, stomach pain or vomiting
  • Yellow skin or eyes (jaundice)

Potential risks and complications

Approximately 15%-25% of people with chronic infection develop chronic liver disease, including cirrhosis, liver failure or liver cancer.

About 9 in 10 infants infected with hepatitis B ultimately develop a chronic infection, with the risk of chronic infection decreasing as the child gets older.

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Measles

Measles is highly contagious and can cause serious health complications, especially in children younger than 5 years old. The disease spreads through the air when an infected person coughs or sneezes, with symptoms appearing seven to 14 days after contact with the virus.

By 2000, due to effective use of vaccines along with collaborative efforts with public health organizations and health care professionals, measles was declared eliminated from the U.S. However, outbreaks continue to occur.

Learn more about measles.

Illustration of small boy with red spots on his arm

Signs and symptoms of measles

  • Fever
  • Cough
  • Runny nose
  • Red, watery eyes
  • Spots in mouth
  • Rash

Potential risks and complications

Complications from measles include ear infections in about 1 in 10 children and diarrhea in fewer than 1 in 10 cases. Some children may suffer from severe complications, such as pneumonia (infection of the lungs) and encephalitis (infection of the brain).

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Mumps

Mumps is caused by a virus that affects the salivary glands. The disease spreads through direct contact with saliva or respiratory droplets from the mouth, nose or throat. It can take two to four weeks for signs of infection to show.

At one time, mumps was the most common cause of acquired deafness in the U.S.

Illustration of boy

Signs and symptoms of mumps

  • Puffy cheeks and a tender, swollen jaw
  • Fever
  • Headache
  • Muscle aches
  • Tiredness
  • Loss of appetite

Potential risks and complications

Although rare, mumps can cause serious complications, which include inflammation of the testicles (a condition known as orchitis).

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Rotavirus

Rotavirus commonly spreads in families, hospitals and child care centers with symptoms usually starting about two days after a person is exposed to the virus. Some symptoms can last three to eight days.

Illustration of baby

Signs and symptoms of rotavirus

  • Severe watery diarrhea
  • Vomiting
  • Fever
  • Stomach pain
  • Dehydration
  • Loss of appetite

Potential risks and complications

Although usually self-limiting, severe illness can result in dehydration with shock leading to hospitalization or, on rare occasions, even death

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Rubella

Rubella, also known as German measles, spreads when an infected person coughs or sneezes. The disease is usually mild with few noticeable symptoms.

About 25 to 50% of people infected with rubella will not experience symptoms but will still be at risk of spreading the infection to others.

Illustration of girl

Signs and symptoms of rubella

  • Fever
  • Headache
  • Mild pink eye (redness or swelling of the white of the eye)
  • General discomfort
  • Swollen and enlarged lymph nodes
  • Cough
  • Runny nose

Potential risks and complications

Rubella is especially dangerous to developing babies during pregnancy. If you’re pregnant and become infected with rubella, there’s an increased risk of having a miscarriage or the baby dying just after birth. The virus can also be passed on to the baby, who may develop congenital rubella syndrome, which includes birth defects such as heart problems, hearing and/or vision problems or developmental delays.

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Understanding disease prevention 

Illustration of doctor and patients

It’s important to learn about the potential risks of these diseases.

Talk to your health care provider about ways to help prevent infectious diseases including appropriate vaccines for you and your family.

Band aid applied to arm

Vaccines: Our history, our legacy

We’ve spent more than a century working to discover and develop vaccines.

Health awareness

Addressing the global shortage of TICE BCG

A new facility will triple our manufacturing capacity and address anticipated global demand for TICE BCG for the foreseeable future

May 30, 2025

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Since 2012, when Merck became the sole manufacturer of TICE® BCG BCG LIVE (for intravesical use) in many locations around the world, increasing global demand has outpaced our current maximum manufacturing capabilities. Committed to producing TICE BCG, in 2021 we announced our plans to construct a new manufacturing facility to significantly expand our production capacity for TICE BCG.

Once fully operational, the new facility will triple our current manufacturing capacity, with supply gradually increasing over time, and address global demand for TICE BCG. We’re investing more than $650 million in the new manufacturing facility, which is expected to be fully operational by late 2026 following inspection, regulatory review and approval.

Warehouse used to maintain inventory of materials used for TICE BCG production

This medicine has a lengthy and complex manufacturing process. Each batch takes more than three months to make, 30 days of which are spent waiting for the growth of a bacteria used to make the medicine.

This investment reaffirms Merck’s longstanding commitment to producing this medicine, and all our medicines, for patients who need them. We recognize the impact supply shortages can have on patients when they can’t receive the medicines they need. Until the new facility is complete, we’ll continue to use a system to proportionally allocate TICE BCG to minimize disruption to patient care as much as possible.

If patients have questions regarding TICE BCG, they should speak with their physicians. Additional information related to the shortage, current allocation practices and our efforts to increase supply, including construction of a new manufacturing site, is below.

What caused the TICE BCG shortages and backorders?

Since 2012, when Merck became the sole manufacturer of TICE® BCG BCG LIVE (for intravesical use) in many locations around the world, increasing global demand has outpaced our current maximum manufacturing capabilities. While we have many years of experience producing TICE BCG, this medicine has a lengthy and inherently complex manufacturing process.

Prior to 2012, additional manufacturers supplied the U.S. market with TICE  BCG, with Merck providing 30-40% of the U.S. supply. As other manufacturers exited the U.S. market in 2012, Merck increased production of TICE BCG to the full extent allowed by our current manufacturing capacity, which effectively doubled our supply of TICE BCG to the U.S. market.


What’s the latest update on the new TICE BCG facility?

Merck is investing more than $650 million to construct a new manufacturing facility to significantly expand production capacity for TICE BCG (first announced in 2021). We expect the facility to be fully operational by late 2026, following inspection, regulatory review and approval, and will address the anticipated demand for TICE BCG.

Once operational, our manufacturing capacity of TICE BCG will triple, and we expect supply to gradually increase over time following local market review and approvals.


How does the TICE BCG allocation process work?

To minimize disruption to patient care as much as possible until the new facility is complete, we’ll continue to use a system to proportionally allocate TICE BCG based on historical demand or in accordance with existing contractual obligations.

Merck allocates available supply among its network of wholesalers and distributors based on historical purchasing patterns or in accordance with existing contractual obligations. In turn, wholesalers and distributors allocate their inventory of TICE BCG to their own customers. End customers, including hospitals or private physician practices, cannot order product directly from Merck. This process is designed to proportionally allocate TICE BCG to minimize disruption to patient care as much as possible.


Where can I find more information about the availability of TICE BCG?

Patients:
Patients should reach out to their physician, as they are in the best position to answer questions about the availability of the medicine in their practice and can inquire about the quantity and timing of product availability with their supplier.

Health care professionals:
Health care professionals with questions regarding allocation should contact their wholesaler or distributor.